Anti-Human Thrombopoietin R/Tpo R Recombinant Antibody (VB22B) (HW601107)

Name: Anti-Human Thrombopoietin R/Tpo R Recombinant Antibody (VB22B)
Brand: abinScience
SKU: HW601107
Price: 191 USD
Availability: InStock

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概要
イメージ
参考文献
データシート
SDS

概要

カタログ番号	HW601107
種反応性	Human
アプリケーション	FCM
宿主種	Mouse
クローン性	Monoclonal
アイソタイプ	IgG1, kappa
クローンID	VB22B
ターゲット	TPO-R, TPOR, Thrombopoietin receptor, MPL, Myeloproliferative leukemia protein, Proto-oncogene c-Mpl, CD110
エンドトキシンレベル	Please contact with the lab for this information.
純度	>95% as determined by SDS-PAGE.
精製	Protein A/G purified from cell culture supernatant.
アクセッション番号	P40238
形態	Liquid
保存バッファー	0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。
安定性と保存	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
背景	Thrombopoietin receptor (CD110/MPL) is a ~71 kDa protein. Receptor for thrombopoietin that regulates hematopoietic stem cell renewal, megakaryocyte differentiation, and platelet formation. Upon activation by THPO, induces rapid tyrosine phosphorylation and activation of JAK2, providing docking sites for many signaling proteins such as STAT5, SHIP/INPP5D, GRB2, SOS1 and PI3K. In turn, These signaling cascades lead to the proliferation, survival, and differentiation of megakaryocytes, ultimately leading to increased platelet production. 1. Royer, Y. et al. (2005) The Journal of biological chemistry 280, 27251-61. PMID: 15899890 2. Tsutsumi, N. et al. (2023) Cell 186, 4189-4203.e22. PMID: 37633268
注意事項	For research use only.

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Bioactivity

Detects CD110/MPL in indirect ELISAs.
Western blot

Western blot analysis was performed using anti-CD110/MPL monoclonal antibody at 1ug/mL on various samples.
Lane 1: recombinant human CD110/MPL (Catalog No: HW601011)
Lane 2: negative control