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Anti-Human Thrombopoietin R/Tpo R Recombinant Antibody (VB22B) (HW601107)

Anti-Human Thrombopoietin R/Tpo R Recombinant Antibody (VB22B)
Anti-Human Thrombopoietin R/Tpo R Recombinant Antibody (VB22B)
Anti-Human Thrombopoietin R/Tpo R Recombinant Antibody (VB22B)
Anti-Human Thrombopoietin R/Tpo R Recombinant Antibody (VB22B)
Цена(USD):
Спецификация:
  • 50ug
  • 100ug
Количество:
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  • Обзор

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  • Ссылки

  • Даташит

  • SDS

Обзор
Каталожный номерHW601107
Реактивность видовHuman
ПримененияFCM
Хозяинский видMouse
КлоональностьMonoclonal
ИзотипIgG1, kappa
ID клонаVB22B
Цель TPO-R, TPOR, Thrombopoietin receptor, MPL, Myeloproliferative leukemia protein, Proto-oncogene c-Mpl, CD110
Уровень эндотоксинов Please contact with the lab for this information.
Чистота >95% as determined by SDS-PAGE.
Очистка Protein A/G purified from cell culture supernatant.
Номер доступа P40238
Форма Liquid
Буфер хранения 0.01M PBS pH 7.4

Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.

Устойчивость и хранение Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Фон

Thrombopoietin receptor (CD110/MPL) is a ~71 kDa protein. Receptor for thrombopoietin that regulates hematopoietic stem cell renewal, megakaryocyte differentiation, and platelet formation. Upon activation by THPO, induces rapid tyrosine phosphorylation and activation of JAK2, providing docking sites for many signaling proteins such as STAT5, SHIP/INPP5D, GRB2, SOS1 and PI3K. In turn, These signaling cascades lead to the proliferation, survival, and differentiation of megakaryocytes, ultimately leading to increased platelet production.

1. Royer, Y. et al. (2005) The Journal of biological chemistry 280, 27251-61. PMID: 15899890
2. Tsutsumi, N. et al. (2023) Cell 186, 4189-4203.e22. PMID: 37633268
Примечание For research use only.
Изображения
  • Anti-Human Thrombopoietin R/Tpo R Recombinant Antibody (VB22B)

    Bioactivity

    Detects CD110/MPL in indirect ELISAs.

  • Anti-Human Thrombopoietin R/Tpo R Recombinant Antibody (VB22B)

    Western blot

    Western blot analysis was performed using anti-CD110/MPL monoclonal antibody at 1ug/mL on various samples.
    Lane 1: recombinant human CD110/MPL (Catalog No: HW601011)
    Lane 2: negative control

Ссылки
Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
×
Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
Рекомендация

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