Anti-Human CD119/IFNGR1 Recombinant Antibody (SAA0044), APC (HB990137)

Name: Anti-Human CD119/IFNGR1 Recombinant Antibody (SAA0044), APC
Brand: abinScience
SKU: HB990137
Price: 290 USD
Availability: InStock

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Каталожный номер	HB990137
Реактивность видов	Human
Применения	FCM
Хозяинский вид	Mouse
Клоональность	Monoclonal
Изотип	IgG1, kappa
ID клона	SAA0044
Конъюгация	APC
Цель	IFN-gamma-R1, Interferon gamma receptor 1, CDw119, Interferon gamma receptor alpha-chain, IFN-gamma receptor 1, IFNGR1, IFN-gamma-R-alpha, CD119
Уровень эндотоксинов	Please contact with the lab for this information.
Связанные продукты	Mouse IgG1, kappa Recombinant Isotype Control Antibody (MOPC-21), APC
Номер доступа	P15260
Форма	Liquid
Буфер хранения	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.
Устойчивость и хранение	Store at 4°C for 12 months. Protect from light. Do not freeze.
Фон	Interferon gamma receptor 1 (CD119/IFNGR1) is a ~54 kDa protein. Receptor subunit for interferon gamma/INFG that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation. Associates with transmembrane accessory factor IFNGR2 to form a functional receptor. Upon ligand binding, the intracellular domain of IFNGR1 opens out to allow association of downstream signaling components JAK1 and JAK2. In turn, activated JAK1 phosphorylates IFNGR1 to form a docking site for STAT1. Subsequent phosphorylation of STAT1 leads to dimerization, translocation to the nucleus, and stimulation of target gene transcription. 1. van de Wetering, D. et al. (2010) Molecular immunology 47, 1023-30. PMID: 20015550 2. Thiel, DJ. et al. (2000) Structure (London, England : 1993) 8, 927-36. PMID: 10986460 3. Aguet, M. et al. (1988) Cell 55, 273-80. PMID: 2971451 4. Sakatsume, M. et al. (1995) The Journal of biological chemistry 270, 17528-34. PMID: 7615558 5. Walter, MR. et al. (1995) Nature 376, 230-5. PMID: 7617032 6. Kotenko, SV. et al. (1995) The Journal of biological chemistry 270, 20915-21. PMID: 7673114 7. Londino, JD. et al. (2017) The Biochemical journal 474, 3543-3557. PMID: 28883123
Примечание	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.

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Anti-Human CD119/IFNGR1 Recombinant Antibody (SAA0044), APC.pdf

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