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| カタログ番号 | HB990127 |
|---|---|
| 種反応性 | Human |
| アプリケーション | FCM |
| 宿主種 | Mouse |
| クローン性 | Monoclonal |
| アイソタイプ | IgG1, kappa |
| クローンID | SAA0044 |
| 抱合 | PE |
| ターゲット | IFN-gamma-R1, Interferon gamma receptor 1, CDw119, Interferon gamma receptor alpha-chain, IFN-gamma receptor 1, IFNGR1, IFN-gamma-R-alpha, CD119 |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 関連製品 | Mouse IgG1, kappa Recombinant Isotype Control Antibody (MOPC-21), PE |
| アクセッション番号 | P15260 |
| 形態 | Liquid |
| 保存バッファー | 0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 安定性と保存 | Store at 4°C for 12 months. Protect from light. Do not freeze. |
| 背景 | Interferon gamma receptor 1 (CD119/IFNGR1) is a ~54 kDa protein. Receptor subunit for interferon gamma/INFG that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation. Associates with transmembrane accessory factor IFNGR2 to form a functional receptor. Upon ligand binding, the intracellular domain of IFNGR1 opens out to allow association of downstream signaling components JAK1 and JAK2. In turn, activated JAK1 phosphorylates IFNGR1 to form a docking site for STAT1. Subsequent phosphorylation of STAT1 leads to dimerization, translocation to the nucleus, and stimulation of target gene transcription. 1. van de Wetering, D. et al. (2010) Molecular immunology 47, 1023-30. PMID: 20015550 2. Thiel, DJ. et al. (2000) Structure (London, England : 1993) 8, 927-36. PMID: 10986460 3. Aguet, M. et al. (1988) Cell 55, 273-80. PMID: 2971451 4. Sakatsume, M. et al. (1995) The Journal of biological chemistry 270, 17528-34. PMID: 7615558 5. Walter, MR. et al. (1995) Nature 376, 230-5. PMID: 7617032 6. Kotenko, SV. et al. (1995) The Journal of biological chemistry 270, 20915-21. PMID: 7673114 7. Londino, JD. et al. (2017) The Biochemical journal 474, 3543-3557. PMID: 28883123 |
| 注意事項 | For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only. |
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