Anti-Human CD119/IFNGR1 Recombinant Antibody (SAA0044), PerCP (HB990147)

Name: Anti-Human CD119/IFNGR1 Recombinant Antibody (SAA0044), PerCP
Brand: abinScience
SKU: HB990147
Price: 268 USD
Availability: InStock

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Numéro de catalogue	HB990147
Reactivité des espèces	Human
Applications	FCM
Espèce hôte	Mouse
Clonalité	Monoclonal
Isotype	IgG1, kappa
ID de clone	SAA0044
Conjugaison	PerCP
Cible	IFN-gamma-R1, Interferon gamma receptor 1, CDw119, Interferon gamma receptor alpha-chain, IFN-gamma receptor 1, IFNGR1, IFN-gamma-R-alpha, CD119
Niveau d'endotoxines	Please contact with the lab for this information.
Produits associés	Mouse IgG1, kappa Recombinant Isotype Control Antibody (MOPC-21), PerCP
Numéro d'accès	P15260
Forme	Liquid
Tampon de stockage	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Stabilité et stockage	Store at 4°C for 12 months. Protect from light. Do not freeze.
Contexte	Interferon gamma receptor 1 (CD119/IFNGR1) is a ~54 kDa protein. Receptor subunit for interferon gamma/INFG that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation. Associates with transmembrane accessory factor IFNGR2 to form a functional receptor. Upon ligand binding, the intracellular domain of IFNGR1 opens out to allow association of downstream signaling components JAK1 and JAK2. In turn, activated JAK1 phosphorylates IFNGR1 to form a docking site for STAT1. Subsequent phosphorylation of STAT1 leads to dimerization, translocation to the nucleus, and stimulation of target gene transcription. 1. van de Wetering, D. et al. (2010) Molecular immunology 47, 1023-30. PMID: 20015550 2. Thiel, DJ. et al. (2000) Structure (London, England : 1993) 8, 927-36. PMID: 10986460 3. Aguet, M. et al. (1988) Cell 55, 273-80. PMID: 2971451 4. Sakatsume, M. et al. (1995) The Journal of biological chemistry 270, 17528-34. PMID: 7615558 5. Walter, MR. et al. (1995) Nature 376, 230-5. PMID: 7617032 6. Kotenko, SV. et al. (1995) The Journal of biological chemistry 270, 20915-21. PMID: 7673114 7. Londino, JD. et al. (2017) The Biochemical journal 474, 3543-3557. PMID: 28883123
Note	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.

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Anti-Human CD119/IFNGR1 Recombinant Antibody (SAA0044), PerCP.pdf

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