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| カタログ番号 | HY474035 |
|---|---|
| 説明 |
Anti-Human CD11b/ITGAM Monoclonal Antibody (1A722) [1A722] (HY474035) is a mouse monoclonal antibody detecting CD11b in ELISA, IHC, WB. Suitable for Human.
Highlights
|
| 種反応性 | Human |
| アプリケーション | ELISA, IHC, WB |
| 宿主種 | Mouse |
| クローン性 | Monoclonal |
| アイソタイプ | IgG |
| クローンID | 1A722 |
| 免疫原 | E. coli - derived recombinant human CD11b/ITGAM (Gln133-Gly337). |
| ターゲット | Integrin alpha-M, CD11 antigen-like family member B, CR-3 alpha chain, Cell surface glycoprotein MAC-1 subunit alpha, Leukocyte adhesion receptor MO1, Neutrophil adherence receptor, CD11b, ITGAM |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >95% as determined by SDS-PAGE. |
| 精製 | Protein A/G purified from cell culture supernatant. |
| アクセッション番号 | P11215 |
| 形態 | Liquid |
| 保存バッファー | 0.01M PBS pH 7.4. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 背景 | Integrin alpha-M (CD11b/ITGAM) is a ~127 kDa protein. Integrin ITGAM/ITGB2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles and pathogens. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin ITGAM/ITGB2 is also a receptor for fibrinogen and factor X. It recognizes P1 and P2 peptides of fibrinogen gamma chain. 1. Losse, J. et al. (2010) Journal of immunology (Baltimore, Md. : 1950) 184, 912-21. PMID: 20008295 2. DiScipio, RG. et al. (1998) Journal of immunology (Baltimore, Md. : 1950) 160, 4057-66. PMID: 9558116 3. Bai, M. et al. (2017) Blood 130, 2092-2100. PMID: 28807980 4. Jerke, U. et al. (2011) The Journal of biological chemistry 286, 7070-81. PMID: 21193407 5. Diamond, MS. et al. (1990) The Journal of cell biology 111, 3129-39. PMID: 1980124 |
| 注意事項 | For research use only. |
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