Anti-Human IL-1 RI Recombinant Antibody (15C4) (HB791207)

Name: Anti-Human IL-1 RI Recombinant Antibody (15C4)
Brand: abinScience
SKU: HB791207
Price: 191 USD
Availability: InStock

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Numéro de catalogue	HB791207
Marque	abinScience
Reactivité des espèces	Human, Monkey
Applications	ELISA, FCM, IF, IHC, SPR, WB
Espèce hôte	Mouse
Clonalité	Monoclonal
Isotype	IgG2a, kappa
ID de clone	15C4
Cible	IL-1RT1, IL-1R-alpha, mIL-1R1, CD121a, IL-1R-1, sIL-1RI, IL1RT1, IL1R1, sIL-1R1, IL1R, CD121 antigen-like family member A, Interleukin-1 receptor type I, Interleukin-1 receptor alpha, mIL-1RI, IL1RA, IL-1RT-1, Interleukin-1 receptor type 1, p80
Niveau d'endotoxines	Please contact with the lab for this information.
Pureté	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Numéro d'accès	P14778
Forme	Liquid
Tampon de stockage	0.01M PBS, pH 7.4, 0.09% Sodium azide. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Stabilité et stockage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Contexte	Interleukin-1 receptor type 1 (CD121a/IL1R1) is a ~65 kDa protein. Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the coreceptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex. Involved in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells. 1. Mosley, B. et al. (1987) The Journal of biological chemistry 262, 2941-4. PMID: 2950091 2. Wang, Y. et al. (2023) Immunity 56, 1485-1501.e7. PMID: 37315560 3. Tominaga, K. et al. (2000) International immunology 12, 151-60. PMID: 10653850
Note	For research use only.