Anti-Human CD136/MST1R Recombinant Antibody (RON8) (HC609107)

Name: Anti-Human CD136/MST1R Recombinant Antibody (RON8)
Brand: abinScience
SKU: HC609107
Price: 191 USD
Availability: InStock

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概要
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参考文献
データシート
SDS

概要

カタログ番号	HC609107
種反応性	Human
アプリケーション	ELISA, FCM, WB
宿主種	Mouse
クローン性	Monoclonal
アイソタイプ	IgG1, kappa
クローンID	RON8
ターゲット	CD136, Macrophage-stimulating protein receptor, PTK8, MST1R, p185-Ron, RON, CDw136, MSP receptor, Protein-tyrosine kinase 8
エンドトキシンレベル	Please contact with the lab for this information.
純度	>95% as determined by SDS-PAGE.
精製	Protein A/G purified from cell culture supernatant.
アクセッション番号	Q04912
形態	Liquid
保存バッファー	0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。
安定性と保存	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
背景	Macrophage-stimulating protein receptor (CD136/MST1R) is a ~152 kDa protein. Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to MST1 ligand. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces autophosphorylation of RON on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1 or the adapter GAB1. Recruitment of these downstream effectors by RON leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC.
注意事項	For research use only.

イメージ

Flow Cytometry

Flow-cytometry using anti-human CD136 antibody.HaCaT cells were stained with an irrelevant antibody (Blue Histogram) or an anti-human CD136 antibody monoclonal antibody (Catalog # HC609107 ,Green Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, bound antibody was detected using a FITC conjugated goat anti-mouse antibody (Catalog # MF690414) and cells analysed on a NovoCyte Flow Cytometer.
Flow Cytometry

Flow-cytometry using anti-human CD136 antibody.SW480 cells were stained with an irrelevant antibody (Blue Histogram) or an anti-human CD136 antibody monoclonal antibody (Catalog # HC609107 ,Green Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, bound antibody was detected using a FITC conjugated goat anti-mouse antibody (Catalog # MF690414) and cells analysed on a NovoCyte Flow Cytometer.