Anti-Human CD136/MST1R Recombinant Antibody (RON8), PE (HC609127)

Name: Anti-Human CD136/MST1R Recombinant Antibody (RON8), PE
Brand: abinScience
SKU: HC609127
Price: 290 USD
Availability: InStock

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Каталожный номер	HC609127
Реактивность видов	Human
Применения	ELISA, FCM, WB
Хозяинский вид	Mouse
Клоональность	Monoclonal
Изотип	IgG1, kappa
ID клона	RON8
Конъюгация	PE
Цель	CD136, Macrophage-stimulating protein receptor, PTK8, MST1R, p185-Ron, RON, CDw136, MSP receptor, Protein-tyrosine kinase 8
Уровень эндотоксинов	Please contact with the lab for this information.
Связанные продукты	Mouse IgG1, kappa Recombinant Isotype Control Antibody (MOPC-21), PE
Номер доступа	Q04912
Форма	Liquid
Буфер хранения	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.
Устойчивость и хранение	Store at 4°C for 12 months. Protect from light. Do not freeze.
Фон	Macrophage-stimulating protein receptor (CD136/MST1R) is a ~152 kDa protein. Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to MST1 ligand. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces autophosphorylation of RON on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1 or the adapter GAB1. Recruitment of these downstream effectors by RON leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC.
Примечание	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.

Изображения

Flow CytoMetry

Flow-cytometry using PE anti-human CD136 antibody. HaCaT cells were stained with an irrelevant antibody (Blue Histogram) or an PE anti-human CD136 monoclonal antibody (Catalog: HC609127, Yellow Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, and cells analysed on a NovoCyte Flow Cytometer.

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