Anti-Human CD14 Recombinant Antibody (18D11) (HY038407)

Name: Anti-Human CD14 Recombinant Antibody (18D11)
Brand: abinScience
SKU: HY038407
Price: 163 USD
Availability: InStock

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Каталожный номер	HY038407
Реактивность видов	Human
Применения	FCM
Хозяинский вид	Mouse
Клоональность	Monoclonal
Изотип	IgG1
ID клона	18D11
Цель	CD14, Monocyte differentiation antigen CD14, Monocyte differentiation antigen CD14, membrane-bound form, Monocyte differentiation antigen CD14, urinary form, My23 antigen, Myeloid cell-specific leucine-rich glycoprotein
Уровень эндотоксинов	< 10 EU/mg
Чистота	>95% as determined by SDS-PAGE.
Очистка	Protein A/G purified from cell culture supernatant.
Номер доступа	P08571
Форма	Liquid
Буфер хранения	0.01M PBS pH 7.4. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.
Устойчивость и хранение	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Фон	Monocyte differentiation antigen CD14 is a ~40 kDa protein. Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway. Binds electronegative LDL (LDL(-)) and mediates the cytokine release induced by LDL(-). 1. Wright, SD. et al. (1990) Science (New York, N.Y.) 249, 1431-3. PMID: 1698311 2. Kelley, SL. et al. (2013) Journal of immunology (Baltimore, Md. : 1950) 190, 1304-11. PMID: 23264655 3. Tsukamoto, H. et al. (2010) International immunology 22, 271-80. PMID: 20133493 4. Murakami, K. et al. (2012) FEBS letters 586, 319-24. PMID: 22265692 5. Haziot, A. et al. (1996) Immunity 4, 407-14. PMID: 8612135 6. Triantafilou, M. et al. (2006) The Journal of biological chemistry 281, 31002-11. PMID: 16880211 7. Estruch, M. et al. (2013) Atherosclerosis 229, 356-62. PMID: 23880187
Примечание	For research use only.