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| カタログ番号 | HY397014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human CD141/THBD Polyclonal Antibody (HY397014) is a rabbit polyclonal antibody detecting CD141 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human CD141/THBD (Ala19-Asp486). | ||||||||
| ターゲット | THBD, THRM, CD141, Thrombomodulin, Fetomodulin, TM | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 純度 | >95% as determined by SDS-PAGE. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P07204 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Thrombomodulin (CD141/THBD) is a ~60 kDa protein. Endothelial cell receptor that plays a critical role in regulating several physiological processes including hemostasis, coagulation, fibrinolysis, inflammation, and angiogenesis. Acts as a cofactor for thrombin activation of protein C/PROC on the surface of vascular endothelial cells leading to initiation of the activated protein C anticoagulant pathway. Also accelerates the activation of the plasma carboxypeptidase B2/CPB2, which catalyzes removal of C-terminal basic amino acids from its substrates including kinins or anaphylatoxins leading to fibrinolysis inhibition. Plays critical protective roles in changing the cleavage specificity of protease-activated receptor 1/PAR1, inhibiting endothelial cell permeability and inflammation. Suppresses inflammation distinctly from its anticoagulant cofactor activity by sequestering HMGB1 thereby preventing it from engaging cellular receptors such as RAGE and contributing to the inflammatory response. 1. Fuentes-Prior, P. et al. (2000) Nature 404, 518-25. PMID: 10761923 2. Daly, C. et al. (2018) Scientific reports 8, 505. PMID: 29323190 3. Giri, H. et al. (2021) Proceedings of the National Academy of Sciences of the United States of America 118. PMID: 33836597 4. Dudek, AZ. et al. (1997) The Journal of biological chemistry 272, 31785-92. PMID: 9395524 5. Wu, C. et al. (2016) Journal of thrombosis and haemostasis : JTH 14, 366-74. PMID: 26663133 6. Abeyama, K. et al. (2005) The Journal of clinical investigation 115, 1267-74. PMID: 15841214 | ||||||||
| 注意事項 | For research use only. |
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