Anti-Human CTLA-4 Recombinant Antibody (SAA2550) (HB651043)

Name: Anti-Human CTLA-4 Recombinant Antibody (SAA2550)
Brand: abinScience
SKU: HB651043
Price: 191 USD
Availability: InStock

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Precio(USD):

Especificación:

50ug
100ug
1mg

Número:

Contáctenos

Vista general
Imágenes
Referencias
Datasheet
SDS

Vista general

Número de catálogo

HB651043

Reactividad de especies

Human

Aplicaciones

ELISA, WB

Clonalidad

Monoclonal

Isotipo

scFv-His

ID de clon

SAA2550

Aplicaciones probadas

Objetivo

CD152, CTLA-4, CTLA4, Cytotoxic T-lymphocyte protein 4, Cytotoxic T-lymphocyte-associated antigen 4

Nivel de endotoxinas

< 10 EU/mg

Pureza

>95% as determined by SDS-PAGE.

Purificación

Purified by Nickel column.

Número de acceso

P16410

Forma

Liquid

Buffer de almacenamiento

0.01M PBS pH 7.4.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Información de uso del producto

Aplicación	Dilución
ELISA	1:2000-1:20000

Estabilidad y almacenamiento

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Fondo

Cytotoxic T-lymphocyte protein 4 (CD152/CTLA4) is a ~24 kDa protein. Inhibitory receptor acting as a major negative regulator of T-cell responses. Acts as a decoy receptor: the affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28. CD152 is the therapeutic target of ipilimumab (Yervoy).

1. Schwartz, JC. et al. (2001) Nature 410, 604-8. PMID: 11279501

2. Stamper, CC. et al. (2001) Nature 410, 608-11. PMID: 11279502

3. Teft, WA. et al. (2006) Annual review of immunology 24, 65-97. PMID: 16551244

4. Linsley, PS. et al. (1991) The Journal of experimental medicine 174, 561-9. PMID: 1714933

5. Zheng, Y. et al. (2008) Journal of immunology (Baltimore, Md. : 1950) 181, 1683-91. PMID: 18641304

6. Ramagopal, UA. et al. (2017) Proceedings of the National Academy of Sciences of the United States of America 114, E4223-E4232. PMID: 28484017

Nota

For research use only

Isotype Control

Anti-Flag Tag (DYKDDDDK) Recombinant Antibody (M2) (YP666033)

Imágenes

SDS-PAGE

SDS-PAGE for Anti-Human CD152/CTLA4 Antibody (SAA2550)
Western blot

Western blot analysis was performed using anti-SCFV-His polyclonal antibody at 1ug/mL on various samples.
Lane 1: Recombinant protein 100ng