Anti-Human ALCAM/CD166 Recombinant Antibody (SAA0066), PE (HC678127)

Name: Anti-Human ALCAM/CD166 Recombinant Antibody (SAA0066), PE
Brand: abinScience
SKU: HC678127
Price: 290 USD
Availability: InStock

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概要
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データシート
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概要

カタログ番号	HC678127
種反応性	Human
アプリケーション	FCM
宿主種	Mouse
クローン性	Monoclonal
アイソタイプ	IgG1, kappa
クローンID	SAA0066
抱合	PE
ターゲット	Activated leukocyte cell adhesion molecule, MEMD, CD166 antigen, ALCAM, CD166
エンドトキシンレベル	Please contact with the lab for this information.
関連製品	Mouse IgG1, kappa Recombinant Isotype Control Antibody (MOPC-21), PE
アクセッション番号	Q13740
形態	Liquid
保存バッファー	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。
安定性と保存	Store at 4°C for 12 months. Protect from light. Do not freeze.
背景	CD166 antigen (ALCAM) is a ~65 kDa protein. Cell adhesion molecule that mediates both heterotypic cell-cell contacts via its interaction with CD6, as well as homotypic cell-cell contacts. Promotes T-cell activation and proliferation via its interactions with CD6. Contributes to the formation and maturation of the immunological synapse via its interactions with CD6. Mediates homotypic interactions with cells that express ALCAM. Acts as a ligand for the LILRB4 receptor, enhancing LILRB4-mediated inhibition of T cell proliferation. 1. Hassan, NJ. et al. (2004) European journal of immunology 34, 930-40. PMID: 15048703 2. Ikeda, K. et al. (2004) The Journal of biological chemistry 279, 55315-23. PMID: 15496415 3. Zimmerman, AW. et al. (2006) Blood 107, 3212-20. PMID: 16352806 4. Iolyeva, M. et al. (2013) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 27, 978-90. PMID: 23169771 5. Escoda-Ferran, C. et al. (2014) FEBS letters 588, 2805-13. PMID: 24945728 6. Bowen, MA. et al. (1995) The Journal of experimental medicine 181, 2213-20. PMID: 7760007 7. Gimferrer, I. et al. (2004) Journal of immunology (Baltimore, Md. : 1950) 173, 2262-70. PMID: 15294938 8. Xu, Z. et al. (2018) Journal of immunology (Baltimore, Md. : 1950) 200, 1207-1219. PMID: 29263213 9. Chitteti, BR. et al. (2014) Blood 124, 519-29. PMID: 24740813
注意事項	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.

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Flow CytoMetry

Flow-cytometry using PE anti-human CD166 antibody. SH-SY5Y cells were stained with an irrelevant antibody (Blue Histogram) or an PE anti-human CD166 monoclonal antibody (Catalog: HC678127, Yellow Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, and cells analysed on a NovoCyte Flow Cytometer.

参考文献

データシート