Anti-Human CD19 Recombinant Nanobody (SAA2078) (HB996043)

Name: Anti-Human CD19 Recombinant Nanobody (SAA2078)
Brand: abinScience
SKU: HB996043
Price: 126 USD
Availability: InStock

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1mg

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Aperçu
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Reférences
Fiche technique
SDS

Aperçu

Numéro de catalogue

HB996043

Description

Anti-Human CD19 Nanobody (SAA2078) [SAA2078] (HB996043) is a alpaca monoclonal antibody detecting CD19 in ELISA. Suitable for Human.

Reactivité des espèces

Human

Applications

ELISA

Espèce hôte

Alpaca

Clonalité

Monoclonal

Isotype

VHH-8His-Cys-tag

ID de clone

SAA2078

Cible

B-lymphocyte antigen CD19, B-lymphocyte surface antigen B4, CD19, Differentiation antigen CD19, T-cell surface antigen Leu-12

Niveau d'endotoxines

< 10 EU/mg

Pureté

>95% as determined by SDS-PAGE.

Purification

Purified by Nickel column.

Numéro d'accès

P15391

Forme

Liquid

Tampon de stockage

0.01M PBS pH 7.4.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:2000-1:20000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Contexte

B-lymphocyte antigen CD19 is a ~61 kDa protein. Functions as a coreceptor for the B-cell antigen receptor complex (BCR) on B-lymphocytes. Decreases the threshold for activation of downstream signaling pathways and for triggering B-cell responses to antigens. Activates signaling pathways that lead to the activation of phosphatidylinositol 3-kinase and the mobilization of intracellular Ca(2+) stores. Is not required for early steps during B cell differentiation in the blood marrow. Required for normal differentiation of B-1 cells. CD19 is the therapeutic target of tafasitamab (Monjuvi).

1. Vanshylla, K. et al. (2018) Scientific reports 8, 4244. PMID: 29523808

2. Carter, RH. et al. (1992) Science (New York, N.Y.) 256, 105-7. PMID: 1373518

3. van Zelm, MC. et al. (2006) The New England journal of medicine 354, 1901-12. PMID: 16672701

4. de Rie, MA. et al. (1989) Cellular immunology 118, 368-81. PMID: 2463100

5. Wang, Y. et al. (2002) Immunity 17, 501-14. PMID: 12387743

6. Sato, S. et al. (1997) Journal of immunology (Baltimore, Md. : 1950) 159, 3278-87. PMID: 9317126

7. Buhl, AM. et al. (1997) The Journal of experimental medicine 186, 1897-910. PMID: 9382888

Note

For research use only.

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