Anti-Human CCR2 Recombinant Antibody (1D9) (HW392107)

Name: Anti-Human CCR2 Recombinant Antibody (1D9)
Brand: abinScience
SKU: HW392107
Price: 191 USD
Availability: InStock

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Vista general

Número de catálogo	HW392107
Reactividad de especies	Human
Aplicaciones	FCM
Especie huésped	Mouse
Clonalidad	Monoclonal
Isotipo	IgG1, kappa
ID de clon	1D9
Objetivo	CCR2, CC-CKR-2, C-C chemokine receptor type 2, CCR-2, C-C CKR-2, MCP-1-R, CMKBR2, CD192, Monocyte chemoattractant protein 1 receptor
Nivel de endotoxinas	Please contact with the lab for this information.
Pureza	>95% as determined by SDS-PAGE.
Purificación	Protein A/G purified from cell culture supernatant.
Número de acceso	P41597
Forma	Liquid
Buffer de almacenamiento	0.01M PBS pH 7.4 Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Estabilidad y almacenamiento	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Fondo	C-C chemokine receptor type 2 (CD192/CCR2) is a ~41 kDa protein. Key functional receptor for CCL2 but can also bind CCL7, and CCL12. Also transduces signaling mediated by CCL13. Its binding with CCL2 on monocytes and macrophages mediates chemotaxis and migration induction through the activation of the PI3K cascade, the small G protein Rac and lamellipodium protrusion. Also acts as a receptor for the beta-defensin DEFB106A/DEFB106B. Regulates the expression of T-cell inflammatory cytokines and T-cell differentiation, promoting the differentiation of T-cells into T-helper 17 cells (Th17) during inflammation. 1. Tan, JHY. et al. (2013) The Journal of biological chemistry 288, 10024-10034. PMID: 23408426 2. Neehus, AL. et al. (2024) Cell 187, 390-408.e23. PMID: 38157855 3. Yamagami, S. et al. (1994) Biochemical and biophysical research communications 202, 1156-62. PMID: 8048929 4. Charo, IF. et al. (1994) Proceedings of the National Academy of Sciences of the United States of America 91, 2752-6. PMID: 8146186 5. De Paula, VS. et al. (2013) Journal of molecular biology 425, 4479-95. PMID: 23938203
Nota	For research use only.

Imágenes

Bioactivity

SEC-HPLC detection for Anti-Human CD192/CCR2 Antibody (1D9).

Referencias

Datasheet

Anti-Human CCR2 Recombinant Antibody (1D9).pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

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C₁ × V₁ = C₂ × V₂

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C₁ (Stock Conc.)

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Working Solution

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