Anti-Human CD21/CR2 Recombinant Antibody (Ab652), APC (HB939337)

Name: Anti-Human CD21/CR2 Recombinant Antibody (Ab652), APC
Brand: abinScience
SKU: HB939337
Price: 290 USD
Availability: InStock

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概要
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データシート
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概要

カタログ番号	HB939337
種反応性	Human
アプリケーション	ELISA, FCM
宿主種	Mouse
クローン性	Monoclonal
アイソタイプ	IgG2a, kappa
クローンID	Ab652
抱合	APC
テスト済みアプリケーション	FCM
ターゲット	Cr2, Complement C3d receptor, C3DR, Epstein-Barr virus receptor, Complement receptor type 2, CR2, EBV receptor, CD21
エンドトキシンレベル	Please contact with the lab for this information.
関連製品	Mouse IgG2a, kappa Recombinant Isotype Control Antibody (MOPC-173), APC
精製	Affinity chromatography.
アクセッション番号	P20023
形態	Liquid
保存バッファー	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。
安定性と保存	Store at 4°C for 12 months. Protect from light. Do not freeze.
背景	Complement receptor type 2 (CD21/CR2) is a ~112 kDa protein. Serves as a receptor for various ligands including complement component CD3d, HNRNPU OR IFNA1. When C3d is bound to antigens, attaches to C3d on B-cell surface and thereby facilitates the recognition and uptake of antigens by B-cells. This interaction enhances B-cell activation and subsequent immune responses. Forms a complex with several partners on the surface of B-cells including CD19, FCRL5 and CD81, to form the B-cell coreceptor complex that plays a crucial role in B-cell activation and signaling. Also induces specific intracellular signaling separately from the BCR and CD19 by activating the tyrosine kinase SRC, which then phosphorylates nucleolin/NCL and triggers AKT and GSK3 kinase activities in a SYK/CD19-independent manner. 1. Delcayre, AX. et al. (1991) The EMBO journal 10, 919-26. PMID: 1849076 2. van den Elsen, JM. et al. (2011) Science (New York, N.Y.) 332, 608-11. PMID: 21527715 3. Barel, M. et al. (1995) Molecular immunology 32, 389-97. PMID: 7753047 4. Bradbury, LE. et al. (1992) Journal of immunology (Baltimore, Md. : 1950) 149, 2841-50. PMID: 1383329 5. Franco, A. et al. (2018) International immunology 30, 569-578. PMID: 30107486 6. Barel, M. et al. (2003) European journal of immunology 33, 2557-66. PMID: 12938232 7. Aubry, JP. et al. (1992) Nature 358, 505-7. PMID: 1386409
注意事項	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.

イメージ

Flow Cytometry

Flow-cytometry using APC anti-Human CD21 antibody. Raji cells were stained with an irrelevant antibody (Green Histogram) or an APC anti-Human CD21 antibody monoclonal antibody (Catalog # HB939337 , Red Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, cells analysed on a NovoCyte Flow Cytometer.

参考文献

データシート