Anti-Human CD222/IGF2R Recombinant Antibody (SAA0540) (HY282107)

Name: Anti-Human CD222/IGF2R Recombinant Antibody (SAA0540)
Brand: abinScience
SKU: HY282107
Price: 196 USD
Availability: InStock

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Número de catálogo	HY282107
Reactividad de especies	Human
Aplicaciones	ELISA, FCM
Especie huésped	Mouse
Clonalidad	Monoclonal
Isotipo	IgG2a, kappa
ID de clon	SAA0540
Objetivo	IGF2R, M6P/IGF2 receptor, 300 kDa mannose 6-phosphate receptor, IGF-II receptor, M6PR, CI-MPR, CD222, Insulin-like growth factor 2 receptor, MPR 300, M6P/IGF2R, MPRI, CI Man-6-P receptor, Insulin-like growth factor II receptor, Cation-independent mannose-6-phosphate receptor
Nivel de endotoxinas	Please contact with the lab for this information.
Pureza	>95% as determined by SDS-PAGE.
Purificación	Protein A/G purified from cell culture supernatant.
Número de acceso	P11717
Forma	Liquid
Buffer de almacenamiento	0.01M PBS, pH 7.4, 0.09% Sodium azide. Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Estabilidad y almacenamiento	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Fondo	Cation-independent mannose-6-phosphate receptor (CD222/IGF2R) is a ~274 kDa protein. Mediates the transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelysosomal compartment where the low pH mediates the dissociation of the complex. The receptor is then recycled back to the Golgi for another round of trafficking through its binding to the retromer. This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation by binding DPP4. 1. McCormick, PJ. et al. (2008) Traffic (Copenhagen, Denmark) 9, 1984-97. PMID: 18817523 2. Oshima, A. et al. (1988) The Journal of biological chemistry 263, 2553-62. PMID: 2963003 3. Brown, J. et al. (2008) The EMBO journal 27, 265-76. PMID: 18046459 4. Ikushima, H. et al. (2000) Proceedings of the National Academy of Sciences of the United States of America 97, 8439-44. PMID: 10900005
Nota	For research use only.