Anti-Human CD222/IGF2R Recombinant Antibody (SAA0540), PE (HY282127)

Name: Anti-Human CD222/IGF2R Recombinant Antibody (SAA0540), PE
Brand: abinScience
SKU: HY282127
Price: 256 USD
Availability: InStock

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Numéro de catalogue	HY282127
Reactivité des espèces	Human
Applications	ELISA, FCM
Espèce hôte	Mouse
Clonalité	Monoclonal
Isotype	IgG2a, kappa
ID de clone	SAA0540
Conjugaison	PE
Cible	IGF2R, M6P/IGF2 receptor, 300 kDa mannose 6-phosphate receptor, IGF-II receptor, M6PR, CI-MPR, CD222, Insulin-like growth factor 2 receptor, MPR 300, M6P/IGF2R, MPRI, CI Man-6-P receptor, Insulin-like growth factor II receptor, Cation-independent mannose-6-phosphate receptor
Niveau d'endotoxines	Please contact with the lab for this information.
Produits associés	Mouse IgG2a, kappa Recombinant Isotype Control Antibody (MOPC-173), PE
Numéro d'accès	P11717
Forme	Liquid
Tampon de stockage	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Stabilité et stockage	Store at 4°C for 12 months. Protect from light. Do not freeze.
Contexte	Cation-independent mannose-6-phosphate receptor (CD222/IGF2R) is a ~274 kDa protein. Mediates the transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelysosomal compartment where the low pH mediates the dissociation of the complex. The receptor is then recycled back to the Golgi for another round of trafficking through its binding to the retromer. This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation by binding DPP4. 1. McCormick, PJ. et al. (2008) Traffic (Copenhagen, Denmark) 9, 1984-97. PMID: 18817523 2. Oshima, A. et al. (1988) The Journal of biological chemistry 263, 2553-62. PMID: 2963003 3. Brown, J. et al. (2008) The EMBO journal 27, 265-76. PMID: 18046459 4. Ikushima, H. et al. (2000) Proceedings of the National Academy of Sciences of the United States of America 97, 8439-44. PMID: 10900005
Note	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.

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Flow CytoMetry

Flow-cytometry using PE anti-human CD222 antibody. HepG-2 cells were fixed and permeabilized, then stained with an irrelevant antibody (Blue Histogram) or an PE anti-human CD222 monoclonal antibody (Catalog: HY282127, Yellow Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, cells analysed on a NovoCyte Flow Cytometer.

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