Anti-Human CD222/IGF2R Recombinant Antibody (SAA0540), PE (HY282127)

Name: Anti-Human CD222/IGF2R Recombinant Antibody (SAA0540), PE
Brand: abinScience
SKU: HY282127
Price: 256 USD
Availability: InStock

Даташит Поделиться продуктом Копировать информацию

Цена(USD):

Спецификация:

50T
100T

Количество:

Свяжитесь с нами

Обзор
Изображения
Ссылки
Даташит
SDS

Обзор

Каталожный номер	HY282127
Реактивность видов	Human
Применения	ELISA, FCM
Хозяинский вид	Mouse
Клоональность	Monoclonal
Изотип	IgG2a, kappa
ID клона	SAA0540
Конъюгация	PE
Цель	IGF2R, M6P/IGF2 receptor, 300 kDa mannose 6-phosphate receptor, IGF-II receptor, M6PR, CI-MPR, CD222, Insulin-like growth factor 2 receptor, MPR 300, M6P/IGF2R, MPRI, CI Man-6-P receptor, Insulin-like growth factor II receptor, Cation-independent mannose-6-phosphate receptor
Уровень эндотоксинов	Please contact with the lab for this information.
Связанные продукты	Mouse IgG2a, kappa Recombinant Isotype Control Antibody (MOPC-173), PE
Номер доступа	P11717
Форма	Liquid
Буфер хранения	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.
Устойчивость и хранение	Store at 4°C for 12 months. Protect from light. Do not freeze.
Фон	Cation-independent mannose-6-phosphate receptor (CD222/IGF2R) is a ~274 kDa protein. Mediates the transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelysosomal compartment where the low pH mediates the dissociation of the complex. The receptor is then recycled back to the Golgi for another round of trafficking through its binding to the retromer. This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation by binding DPP4. 1. McCormick, PJ. et al. (2008) Traffic (Copenhagen, Denmark) 9, 1984-97. PMID: 18817523 2. Oshima, A. et al. (1988) The Journal of biological chemistry 263, 2553-62. PMID: 2963003 3. Brown, J. et al. (2008) The EMBO journal 27, 265-76. PMID: 18046459 4. Ikushima, H. et al. (2000) Proceedings of the National Academy of Sciences of the United States of America 97, 8439-44. PMID: 10900005
Примечание	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.

Изображения

Flow CytoMetry

Flow-cytometry using PE anti-human CD222 antibody. HepG-2 cells were fixed and permeabilized, then stained with an irrelevant antibody (Blue Histogram) or an PE anti-human CD222 monoclonal antibody (Catalog: HY282127, Yellow Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, cells analysed on a NovoCyte Flow Cytometer.

Ссылки

Даташит