Anti-Human ALK/CD246 Recombinant Antibody (ab324) (HV427107)

Name: Anti-Human ALK/CD246 Recombinant Antibody (ab324)
Brand: abinScience
SKU: HV427107
Price: 191 USD
Availability: InStock

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Каталожный номер	HV427107
Реактивность видов	Human
Применения	FCM
Хозяинский вид	Mouse
Клоональность	Monoclonal
Изотип	IgG1, kappa
ID клона	ab324
Цель	ALK, ALK tyrosine kinase receptor, CD246, Anaplastic lymphoma kinase
Уровень эндотоксинов	Please contact with the lab for this information.
Чистота	>95% as determined by SDS-PAGE.
Очистка	Protein A/G purified from cell culture supernatant.
Номер доступа	Q9UM73
Форма	Liquid
Буфер хранения	0.01M PBS pH 7.4 Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.
Устойчивость и хранение	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Фон	ALK tyrosine kinase receptor (CD246) is a ~176 kDa protein. Neuronal receptor tyrosine kinase that is essentially and transiently expressed in specific regions of the central and peripheral nervous systems and plays an important role in the genesis and differentiation of the nervous system. Also acts as a key thinness protein involved in the resistance to weight gain: in hypothalamic neurons, controls energy expenditure acting as a negative regulator of white adipose tissue lipolysis and sympathetic tone to fine-tune energy homeostasis. Following activation by ALKAL2 ligand at the cell surface, transduces an extracellular signal into an intracellular response. In contrast, ALKAL1 is not a potent physiological ligand for ALK. Ligand-binding to the extracellular domain induces tyrosine kinase activation, leading to activation of the mitogen-activated protein kinase (MAPK) pathway. 1. Souttou, B. et al. (2001) The Journal of biological chemistry 276, 9526-31. PMID: 11121404 2. Simonitsch, I. et al. (2001) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 15, 1416-8. PMID: 11387242 3. Gouzi, JY. et al. (2005) Journal of cell science 118, 5811-23. PMID: 16317043 4. Degoutin, J. et al. (2007) FEBS letters 581, 727-34. PMID: 17274988 5. Reshetnyak, AV. et al. (2018) Proceedings of the National Academy of Sciences of the United States of America 115, 8340-8345. PMID: 30061385 6. De Munck, S. et al. (2021) Nature 600, 143-147. PMID: 34646012 7. Reshetnyak, AV. et al. (2021) Nature 600, 153-157. PMID: 34819673 8. Borenäs, M. et al. (2021) The EMBO journal 40, e105784. PMID: 33411331
Примечание	For research use only.

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Flow Cytometry

Flow-cytometry using anti-human CD246 antibody.CD246 Transfected HI5 cells were stained with an irrelevant antibody (Blue Histogram) or an anti-human CD246 antibody monoclonal antibody (Catalog # HV427107 ,Green Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, bound antibody was detected using a FITC conjugated goat anti-mouse antibody (Catalog # MF690414) and cells analysed on a NovoCyte Flow Cytometer.

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