Anti-Human Endosialin/CD248 Recombinant Antibody (SAA0182), PE (HV681127)

Name: Anti-Human Endosialin/CD248 Recombinant Antibody (SAA0182), PE
Brand: abinScience
SKU: HV681127
Price: 290 USD
Availability: InStock

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Numéro de catalogue	HV681127
Reactivité des espèces	Human
Applications	FCM
Espèce hôte	Human
Clonalité	Monoclonal
Isotype	IgG1, kappa
ID de clone	SAA0182
Conjugaison	PE
Cible	Endosialin, TEM1, CD164L1, Tumor endothelial marker 1, CD248
Niveau d'endotoxines	Please contact with the lab for this information.
Produits associés	Human IgG1 Recombinant Isotype Control Antibody (HyHEL-10), PE
Numéro d'accès	Q9HCU0
Forme	Liquid
Tampon de stockage	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Stabilité et stockage	Store at 4°C for 12 months. Protect from light. Do not freeze.
Contexte	Endosialin (CD248) is a ~80 kDa protein. Cell surface glycoprotein involved in various biological processes including angiogenesis, immune response modulation, and tissue remodeling and repair. Participates in pericyte proliferation through positive modulation of the PDGF receptor signaling pathway. Acts as a scaffold for factor X, triggering allosteric changes and the spatial re-alignment of factor X with the TF-factor VIIa complex, thereby enhancing coagulation activation. Modulates the insulin signaling pathway by interacting with insulin receptor/INSR and by diminishing its capacity to be autophosphorylated in response to insulin. Also regulates LPS-induced inflammatory response in macrophages by favoring the production of proinflammatory cytokines. 1. Tomkowicz, B. et al. (2010) Cancer biology & therapy 9, 908-15. PMID: 20484976 2. Hardie, DL. et al. (2011) Immunology 133, 288-95. PMID: 21466550
Note	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.