Anti-Human CD270/TNFRSF14 Recombinant Antibody (36H12), FITC (HV480117)

Name: Anti-Human CD270/TNFRSF14 Recombinant Antibody (36H12), FITC
Brand: abinScience
SKU: HV480117
Price: 223 USD
Availability: InStock

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Número de catálogo	HV480117
Reactividad de especies	Human
Aplicaciones	FCM
Especie huésped	Mouse
Clonalidad	Monoclonal
Isotipo	IgG1, kappa
ID de clon	36H12
Conjugación	FITC
Objetivo	HVEA, HVEM, Herpes virus entry mediator A, Tumor necrosis factor receptor superfamily member 14, Tumor necrosis factor receptor-like 2, HveA, TNFRSF14, CD270, TR2, Herpesvirus entry mediator A
Nivel de endotoxinas	< 10 EU/mg
Pureza	>90% as determined by SDS-PAGE.
Productos asociados	Mouse IgG1, kappa Recombinant Isotype Control Antibody (MOPC-21), FITC
Número de acceso	Q92956
Forma	Liquid
Buffer de almacenamiento	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Estabilidad y almacenamiento	Store at 4°C for 12 months. Protect from light. Do not freeze.
Fondo	Tumor necrosis factor receptor superfamily member 14 (CD270/TNFRSF14) is a ~30 kDa protein. Receptor for four distinct ligands: The TNF superfamily members TNFSF14/LIGHT and homotrimeric LTA/lymphotoxin-alpha and the immunoglobulin superfamily members BTLA and CD160, altogether defining a complex stimulatory and inhibitory signaling network. Signals via the TRAF2-TRAF3 E3 ligase pathway to promote immune cell survival and differentiation. Participates in bidirectional cell-cell contact signaling between antigen presenting cells and lymphocytes. In response to ligation of TNFSF14/LIGHT, delivers costimulatory signals to T cells, promoting cell proliferation and effector functions. Interacts with CD160 on NK cells, enhancing IFNG production and anti-tumor immune response. 1. Tamada, K. et al. (2000) Journal of immunology (Baltimore, Md. : 1950) 164, 4105-10. PMID: 10754304 2. Cai, G. et al. (2008) Nature immunology 9, 176-85. PMID: 18193050 3. Šedý, JR. et al. (2013) Journal of immunology (Baltimore, Md. : 1950) 191, 828-36. PMID: 23761635 4. Mauri, DN. et al. (1998) Immunity 8, 21-30. PMID: 9462508 5. Cheung, TC. et al. (2009) Journal of immunology (Baltimore, Md. : 1950) 183, 7286-96. PMID: 19915044 6. Hsu, H. et al. (1997) The Journal of biological chemistry 272, 13471-4. PMID: 9153189 7. Marsters, SA. et al. (1997) The Journal of biological chemistry 272, 14029-32. PMID: 9162022
Nota	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.

Imágenes

Flow cytometry

Flow-cytometry FITC using anti-human CD270 antibody. Untransfected cells (blue Histogram) and Transfected cells (Yellow Histogram) were stained with an FITC anti-human CD270 monoclonal antibody (Catalog HV480117) at a concentration of 5 µg/ml for 30 mins at RT. After washing, cells analysed on a NovoCyte Flow Cytometer.

Referencias

Datasheet

Anti-Human CD270/TNFRSF14 Recombinant Antibody (36H12), FITC.pdf

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