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| カタログ番号 | HV375127 |
|---|---|
| 種反応性 | Human |
| アプリケーション | FCM |
| 宿主種 | Human |
| クローン性 | Monoclonal |
| アイソタイプ | IgG4, kappa |
| クローンID | SAA0087 |
| 抱合 | PE |
| ターゲット | B- and T-lymphocyte attenuator, BTLA, CD272, B- and T-lymphocyte-associated protein |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 関連製品 | Human IgG4 (S228P) Recombinant Isotype Control Antibody (13R4), PE |
| アクセッション番号 | Q7Z6A9 |
| 形態 | Liquid |
| 保存バッファー | 0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 安定性と保存 | Store at 4°C for 12 months. Protect from light. Do not freeze. |
| 背景 | B- and T-lymphocyte attenuator (CD272/BTLA) is a ~32 kDa protein. Inhibitory receptor on lymphocytes that negatively regulates antigen receptor signaling via PTPN6/SHP-1 and PTPN11/SHP-2. May interact in cis (on the same cell) or in trans (on other cells) with TNFRSF14. In cis interactions, appears to play an immune regulatory role inhibiting in trans interactions in naive T cells to maintain a resting state. In trans interactions, can predominate during adaptive immune response to provide survival signals to effector T cells. _x005F_x000D_ _x005F_x000D_1. Watanabe, N. et al. (2003) Nature immunology 4, 670-9. PMID: 12796776 _x005F_x000D_
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2. Gavrieli, M. et al. (2003) Biochemical and biophysical research communications 312, 1236-43. PMID: 14652006 _x005F_x000D_
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3. Sedy, JR. et al. (2005) Nature immunology 6, 90-8. PMID: 15568026 _x005F_x000D_
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4. Cai, G. et al. (2008) Nature immunology 9, 176-85. PMID: 18193050 _x005F_x000D_
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5. Cheung, TC. et al. (2009) Journal of immunology (Baltimore, Md. : 1950) 183, 7286-96. PMID: 19915044 |
| 注意事項 | For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only. |
Flow-cytometry PE using anti-human CD272 antibody. Untransfected cells (blue Histogram) and Transfected cells (Yellow Histogram) were stained with an PE anti-human CD272 monoclonal antibody (Catalog HV375127) at a concentration of 5 µg/ml for 30 mins at RT. After washing, cells analysed on a NovoCyte Flow Cytometer.
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