Anti-Human PD-L1 Recombinant Antibody (405.9A11) (HV974093)

Name: Anti-Human PD-L1 Recombinant Antibody (405.9A11)
Brand: abinScience
SKU: HV974093
Price: 126 USD
Availability: InStock

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Precio(USD):

Especificación:

20ug
50ug
100ug
1mg

Número:

Contáctenos

Vista general
Imágenes
Referencias
Datasheet
SDS

Vista general

Número de catálogo

HV974093

Reactividad de especies

Human

Aplicaciones

IHC, WB

Especie huésped

Mouse

Clonalidad

Monoclonal

Isotipo

IgG1

ID de clon

405.9A11

Objetivo

B7 homolog 1, B7-H1, B7H1, CD274, PD-L1, PDCD1 ligand 1, PDCD1L1, PDCD1LG1, PDL1, Programmed cell death 1 ligand 1, Programmed death ligand 1

Nivel de endotoxinas

< 10 EU/mg

Pureza

>95% as determined by SDS-PAGE.

Purificación

Protein A/G purified from cell culture supernatant.

Número de acceso

Q9NZQ7

RRID

Anti-Human CD274/PD-L1/B7-H1 Antibody (405.9A11) (abinScience Cat# HV974093, RRID:AB_3729397)

Forma

Liquid

Buffer de almacenamiento

0.01M PBS pH 7.4.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Información de uso del producto

Aplicación	Dilución
WB	1:500-1:2000

Estabilidad y almacenamiento

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Fondo

B-lymphocyte antigen CD19 (CD274/PD-L1) is a ~61 kDa protein. Functions as a coreceptor for the B-cell antigen receptor complex (BCR) on B-lymphocytes. Decreases the threshold for activation of downstream signaling pathways and for triggering B-cell responses to antigens. Activates signaling pathways that lead to the activation of phosphatidylinositol 3-kinase and the mobilization of intracellular Ca(2+) stores. Is not required for early steps during B cell differentiation in the blood marrow. Required for normal differentiation of B-1 cells. CD274 is the therapeutic target of atezolizumab (Tecentriq) and durvalumab (Imfinzi).

1. Vanshylla, K. et al. (2018) Scientific reports 8, 4244. PMID: 29523808

2. Carter, RH. et al. (1992) Science (New York, N.Y.) 256, 105-7. PMID: 1373518

3. van Zelm, MC. et al. (2006) The New England journal of medicine 354, 1901-12. PMID: 16672701

4. de Rie, MA. et al. (1989) Cellular immunology 118, 368-81. PMID: 2463100

5. Wang, Y. et al. (2002) Immunity 17, 501-14. PMID: 12387743

6. Sato, S. et al. (1997) Journal of immunology (Baltimore, Md. : 1950) 159, 3278-87. PMID: 9317126

7. Buhl, AM. et al. (1997) The Journal of experimental medicine 186, 1897-910. PMID: 9382888

Nota

For research use only.

Isotype Control

Mouse IgG1, kappa Recombinant Isotype Control Antibody (MOPC-21) (MV080207)

Imágenes