Anti-Human CD284/TLR4 Recombinant Antibody (SAA0095), FITC (HT205117)

Name: Anti-Human CD284/TLR4 Recombinant Antibody (SAA0095), FITC
Brand: abinScience
SKU: HT205117
Price: 223 USD
Availability: InStock

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Numéro de catalogue	HT205117
Reactivité des espèces	Human
Applications	FCM
Espèce hôte	Mouse
Clonalité	Monoclonal
Isotype	IgG1
ID de clone	SAA0095
Conjugaison	FITC
Cible	Toll-like receptor 4, TLR4, CD284, hToll
Niveau d'endotoxines	Please contact with the lab for this information.
Produits associés	Mouse IgG1 Recombinant Isotype Control Antibody (HyHEL-10), FITC
Numéro d'accès	O00206
Forme	Liquid
Tampon de stockage	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Stabilité et stockage	Store at 4°C for 12 months. Protect from light. Do not freeze.
Contexte	Toll-like receptor 4 (CD284/TLR4) is a ~95 kDa protein. Transmembrane receptor that functions as a pattern recognition receptor recognizing pathogen- and damage-associated molecular patterns (PAMPs and DAMPs) to induce innate immune responses via downstream signaling pathways. At the plasma membrane, cooperates with LY96 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate, and Ni(2+). Mechanistically, acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Alternatively, CD14-mediated TLR4 internalization via endocytosis is associated with the initiation of a MYD88-independent signaling via the TICAM1-TBK1-IRF3 axis leading to type I interferon production. 1. Arbour, NC. et al. (2000) Nature genetics 25, 187-91. PMID: 10835634 2. Bulut, Y. et al. (2005) The Journal of biological chemistry 280, 20961-7. PMID: 15809303 3. Jung, SB. et al. (2006) Infection and immunity 74, 2686-96. PMID: 16622205 4. Georgel, P. et al. (2007) Virology 362, 304-13. PMID: 17292937 5. Kim, F. et al. (2007) Circulation research 100, 1589-96. PMID: 17478729 6. Stewart, CR. et al. (2010) Nature immunology 11, 155-61. PMID: 20037584 7. Schmidt, M. et al. (2010) Nature immunology 11, 814-9. PMID: 20711192 8. Estruch, M. et al. (2013) Atherosclerosis 229, 356-62. PMID: 23880187 9. Tatematsu, M. et al. (2016) Journal of immunology (Baltimore, Md. : 1950) 196, 3865-76. PMID: 27022195 10. Xiahou, Z. et al. (2017) Nature communications 8, 950. PMID: 29038465
Note	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.