Anti-Human CD284/TLR4 Recombinant Antibody (SAA0095) (HT205107)

Name: Anti-Human CD284/TLR4 Recombinant Antibody (SAA0095)
Brand: abinScience
SKU: HT205107
Price: 191 USD
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Número de catálogo	HT205107
Reactividad de especies	Human
Aplicaciones	FCM
Especie huésped	Mouse
Clonalidad	Monoclonal
Isotipo	IgG1
ID de clon	SAA0095
Objetivo	Toll-like receptor 4, TLR4, CD284, hToll
Nivel de endotoxinas	Please contact with the lab for this information.
Pureza	>95% as determined by SDS-PAGE.
Purificación	Protein A/G purified from cell culture supernatant.
Número de acceso	O00206
Forma	Liquid
Buffer de almacenamiento	0.01M PBS pH 7.4 Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Estabilidad y almacenamiento	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Fondo	Toll-like receptor 4 (CD284/TLR4) is a ~95 kDa protein. Transmembrane receptor that functions as a pattern recognition receptor recognizing pathogen- and damage-associated molecular patterns (PAMPs and DAMPs) to induce innate immune responses via downstream signaling pathways. At the plasma membrane, cooperates with LY96 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate, and Ni(2+). Mechanistically, acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Alternatively, CD14-mediated TLR4 internalization via endocytosis is associated with the initiation of a MYD88-independent signaling via the TICAM1-TBK1-IRF3 axis leading to type I interferon production. 1. Arbour, NC. et al. (2000) Nature genetics 25, 187-91. PMID: 10835634 2. Bulut, Y. et al. (2005) The Journal of biological chemistry 280, 20961-7. PMID: 15809303 3. Jung, SB. et al. (2006) Infection and immunity 74, 2686-96. PMID: 16622205 4. Georgel, P. et al. (2007) Virology 362, 304-13. PMID: 17292937 5. Kim, F. et al. (2007) Circulation research 100, 1589-96. PMID: 17478729 6. Stewart, CR. et al. (2010) Nature immunology 11, 155-61. PMID: 20037584 7. Schmidt, M. et al. (2010) Nature immunology 11, 814-9. PMID: 20711192 8. Estruch, M. et al. (2013) Atherosclerosis 229, 356-62. PMID: 23880187 9. Tatematsu, M. et al. (2016) Journal of immunology (Baltimore, Md. : 1950) 196, 3865-76. PMID: 27022195 10. Xiahou, Z. et al. (2017) Nature communications 8, 950. PMID: 29038465
Nota	For research use only.