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| カタログ番号 | HV834107 |
|---|---|
| 種反応性 | Human |
| アプリケーション | FCM |
| 宿主種 | Mouse |
| クローン性 | Monoclonal |
| アイソタイプ | IgG1, kappa |
| クローンID | 49C11 |
| ターゲット | CD301, Macrophage lectin 2, C-type lectin domain family 10 member A, CLECSF13, C-type lectin superfamily member 14, CLEC10A, CLECSF14, HML |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >95% as determined by SDS-PAGE. |
| 精製 | Protein A/G purified from cell culture supernatant. |
| アクセッション番号 | Q8IUN9 |
| 形態 | Liquid |
| 保存バッファー | 0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. |
| 背景 | C-type lectin domain family 10 member A (CD301/CLEC10A) is a ~35 kDa protein. C-type lectin receptor involved in recognition of N-acetylgalactosamine (GalNAc)-terminated glycans by myeloid antigen presenting cells (APCs). Binds in a Ca(2+)-dependent manner to alpha- and beta-linked GalNAc residues on glycoprotein and glycolipid antigens, including alphaGalNAc- and Galbeta1->3GalNAc-O-Ser/Thr also known as Tn and T antigens, LacdiNAc epitope GalNAcbeta1->4GlcNAc and its derivative GalNAcbeta1->4-(Fucalpha1->3)GlcNAc, O-linked core 5 and 6 glycans, and GM2 and GD2 gangliosides. Acts as a signaling receptor at the interface of APC-T cell interactions. On immature dendritic cells, recognizes Tn antigen-carrying PTPRC/CD45 receptor on effector T cells and downregulates PTRPN/CD45 phosphatase activity with an impact on T cell activation threshold, cytokine production and proliferation. Modulates dendritic cell maturation toward a tolerogenic phenotype leading to generation of regulatory CD4-positive T cell subset with immune suppressive functions. 1. van Vliet, SJ. et al. (2005) International immunology 17, 661-9. PMID: 15802303 2. van Vliet, SJ. et al. (2006) Nature immunology 7, 1200-8. PMID: 16998493 3. van Vliet, SJ. et al. (2007) European journal of immunology 37, 2075-81. PMID: 17616966 4. Li, D. et al. (2012) The Journal of experimental medicine 209, 109-21. PMID: 22213806 5. Gabba, A. et al. (2021) Biochemistry 60, 1327-1336. PMID: 33724805 6. Suzuki, N. et al. (1996) Journal of immunology (Baltimore, Md. : 1950) 156, 128-35. PMID: 8598452 7. Mortezai, N. et al. (2013) Glycobiology 23, 844-52. PMID: 23507963 |
| 注意事項 | For research use only. |
Detects CD301/CLEC10A in indirect ELISAs.
Western blot analysis was performed using anti-CD301/CLEC10A monoclonal antibody at 1ug/mL on various samples.
Lane 1: recombinant human CD301/CLEC10A (Catalog No: HV834011)
Lane 2: negative control
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