Anti-Human LAIR1 Recombinant Antibody (LA-94) (HV765107)

Name: Anti-Human LAIR1 Recombinant Antibody (LA-94)
Brand: abinScience
SKU: HV765107
Price: 191 USD
Availability: InStock

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Aperçu

Numéro de catalogue	HV765107
Reactivité des espèces	Human
Applications	FCM
Espèce hôte	Mouse
Clonalité	Monoclonal
Isotype	IgG2a, kappa
ID de clone	LA-94
Cible	Leukocyte-associated immunoglobulin-like receptor 1, LAIR-1, hLAIR1, LAIR1, CD305
Niveau d'endotoxines	Please contact with the lab for this information.
Pureté	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Numéro d'accès	Q6GTX8
Forme	Liquid
Tampon de stockage	0.01M PBS pH 7.4 Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Stabilité et stockage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Contexte	Leukocyte-associated immunoglobulin-like receptor 1 (CD305/LAIR1) is a ~31 kDa protein. Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. May also play its inhibitory role independently of SH2-containing phosphatases. Modulates cytokine production in CD4+ T-cells, down-regulating IL2 and IFNG production while inducing secretion of transforming growth factor beta.
Note	For research use only.

Images

Western blot

Western blot analysis was performed using anti-CD305/LAIR1 monoclonal antibody at 1ug/mL on various samples.
Lane 1: recombinant human CD305/LAIR1 (Catalog No: HV765011)
Lane 2: negative control
Bioactivity

Detects recombinant CD305 (Catalog No: HV765011) in indirect ELISA.