Anti-Human CD338/ABCG2 Recombinant Antibody (5D3) (HV314107)

Name: Anti-Human CD338/ABCG2 Recombinant Antibody (5D3)
Brand: abinScience
SKU: HV314107
Price: 191 USD
Availability: InStock

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Vista general

Número de catálogo	HV314107
Reactividad de especies	Human
Aplicaciones	FCM
Especie huésped	Mouse
Clonalidad	Monoclonal
Isotipo	IgG1, kappa
ID de clon	5D3
Objetivo	Urate exporter, ABCP, BCRP1, ABCG2, CD338, BCRP, MXR, Broad substrate specificity ATP-binding cassette transporter ABCG2, Placenta-specific ATP-binding cassette transporter, Breast cancer resistance protein, Mitoxantrone resistance-associated protein, CDw338, ATP-binding cassette sub-family G member 2
Nivel de endotoxinas	Please contact with the lab for this information.
Pureza	>95% as determined by SDS-PAGE.
Purificación	Protein A/G purified from cell culture supernatant.
Número de acceso	Q9UNQ0
Forma	Liquid
Buffer de almacenamiento	0.01M PBS pH 7.4 Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Estabilidad y almacenamiento	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Fondo	Broad substrate specificity ATP-binding cassette transporter ABCG2 (CD338) is a ~72 kDa protein. Broad substrate specificity ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes a wide variety of physiological compounds, dietary toxins and xenobiotics from cells. Involved in porphyrin homeostasis, mediating the export of protoporphyrin IX (PPIX) from both mitochondria to cytosol and cytosol to extracellular space, it also functions in the cellular export of heme. Also mediates the efflux of sphingosine-1-P from cells. Acts as a urate exporter functioning in both renal and extrarenal urate excretion. In kidney, it also functions as a physiological exporter of the uremic toxin indoxyl sulfate. 1. Komatani, H. et al. (2001) Cancer research 61, 2827-32. PMID: 11306452 2. Zhang, W. et al. (2003) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 17, 2085-7. PMID: 12958161 3. Woodward, OM. et al. (2009) Proceedings of the National Academy of Sciences of the United States of America 106, 10338-42. PMID: 19506252 4. Desuzinges-Mandon, E. et al. (2010) The Journal of biological chemistry 285, 33123-33133. PMID: 20705604 5. Taylor, NMI. et al. (2017) Nature 546, 504-509. PMID: 28554189 6. Manolaridis, I. et al. (2018) Nature 563, 426-430. PMID: 30405239 7. Toyoda, Y. et al. (2019) Cells 8. PMID: 31003562 8. Kobuchi, H. et al. (2012) PloS one 7, e50082. PMID: 23189181 9. Takabe, K. et al. (2010) The Journal of biological chemistry 285, 10477-86. PMID: 20110355
Nota	For research use only.

Imágenes

Flow Cytometry

Flow-cytometry using anti-human CD338 antibody.MCF7 cells were stained with an irrelevant antibody (Blue Histogram) or an anti-human CD338 antibody monoclonal antibody (Catalog # HV314107 ,Green Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, bound antibody was detected using a FITC conjugated goat anti-mouse antibody (Catalog # MF690414) and cells analysed on a NovoCyte Flow Cytometer.

Referencias

Datasheet

Anti-Human CD338/ABCG2 Recombinant Antibody (5D3).pdf

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Formula

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