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| カタログ番号 | HV314107 |
|---|---|
| 種反応性 | Human |
| アプリケーション | FCM |
| 宿主種 | Mouse |
| クローン性 | Monoclonal |
| アイソタイプ | IgG1, kappa |
| クローンID | 5D3 |
| ターゲット | Urate exporter, ABCP, BCRP1, ABCG2, CD338, BCRP, MXR, Broad substrate specificity ATP-binding cassette transporter ABCG2, Placenta-specific ATP-binding cassette transporter, Breast cancer resistance protein, Mitoxantrone resistance-associated protein, CDw338, ATP-binding cassette sub-family G member 2 |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >95% as determined by SDS-PAGE. |
| 精製 | Protein A/G purified from cell culture supernatant. |
| アクセッション番号 | Q9UNQ0 |
| 形態 | Liquid |
| 保存バッファー | 0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. |
| 背景 | Broad substrate specificity ATP-binding cassette transporter ABCG2 (CD338) is a ~72 kDa protein. Broad substrate specificity ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes a wide variety of physiological compounds, dietary toxins and xenobiotics from cells. Involved in porphyrin homeostasis, mediating the export of protoporphyrin IX (PPIX) from both mitochondria to cytosol and cytosol to extracellular space, it also functions in the cellular export of heme. Also mediates the efflux of sphingosine-1-P from cells. Acts as a urate exporter functioning in both renal and extrarenal urate excretion. In kidney, it also functions as a physiological exporter of the uremic toxin indoxyl sulfate. 1. Komatani, H. et al. (2001) Cancer research 61, 2827-32. PMID: 11306452 2. Zhang, W. et al. (2003) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 17, 2085-7. PMID: 12958161 3. Woodward, OM. et al. (2009) Proceedings of the National Academy of Sciences of the United States of America 106, 10338-42. PMID: 19506252 4. Desuzinges-Mandon, E. et al. (2010) The Journal of biological chemistry 285, 33123-33133. PMID: 20705604 5. Taylor, NMI. et al. (2017) Nature 546, 504-509. PMID: 28554189 6. Manolaridis, I. et al. (2018) Nature 563, 426-430. PMID: 30405239 7. Toyoda, Y. et al. (2019) Cells 8. PMID: 31003562 8. Kobuchi, H. et al. (2012) PloS one 7, e50082. PMID: 23189181 9. Takabe, K. et al. (2010) The Journal of biological chemistry 285, 10477-86. PMID: 20110355 |
| 注意事項 | For research use only. |
Flow-cytometry using anti-human CD338 antibody.MCF7 cells were stained with an irrelevant antibody (Blue Histogram) or an anti-human CD338 antibody monoclonal antibody (Catalog # HV314107 ,Green Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, bound antibody was detected using a FITC conjugated goat anti-mouse antibody (Catalog # MF690414) and cells analysed on a NovoCyte Flow Cytometer.
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