

| Каталожный номер | HY286063 | ||||||
|---|---|---|---|---|---|---|---|
| Реактивность видов | Human | ||||||
| Применения | ELISA, IF, WB | ||||||
| Хозяинский вид | Mouse | ||||||
| Клоональность | Monoclonal | ||||||
| Изотип | IgG2a, kappa | ||||||
| ID клона | FRP5 | ||||||
| Цель | CD340, EC:2.7.10.1, ERBB2, HER2, MLN 19, MLN19, Metastatic lymph node gene 19 protein, NEU, NGL, Proto-oncogene Neu, Proto-oncogene c-ErbB-2, Receptor tyrosine-protein kinase erbB-2, Tyrosine kinase-type cell surface receptor HER2, p185erbB2 | ||||||
| Уровень эндотоксинов | < 10 EU/mg | ||||||
| Чистота | >95% as determined by SDS-PAGE. | ||||||
| Очистка | Protein A/G purified from cell culture supernatant. | ||||||
| Номер доступа | P04626 | ||||||
| RRID | Anti-Human CD340/ERBB2/HER2 Antibody (FRP5) (abinScience Cat# HY286063, RRID:AB_3729458) |
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| Форма | Liquid | ||||||
| Буфер хранения | 0.01M PBS pH 7.4. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии. |
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| Информация об использовании продукта |
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| Устойчивость и хранение | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||
| Фон | Receptor tyrosine-protein kinase erbB-2 (CD340/ERBB2) is a ~137 kDa protein. Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. CD340 is the therapeutic target of trastuzumab (Herceptin) and trastuzumab deruxtecan (Enhertu). | ||||||
| Примечание | For research use only. |

SDS-PAGE for Anti-Human CD340/ERBB2/HER2 Antibody (FRP5)
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