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Anti-Human CD35 Monoclonal Antibody (1A629) (HB625035)

Anti-Human CD35 Monoclonal Antibody (1A629)
Anti-Human CD35 Monoclonal Antibody (1A629)
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Aperçu
Numéro de catalogueHB625035
Description
Anti-Human CD35/CR1 Monoclonal Antibody (1A629) [1A629] (HB625035) is a mouse monoclonal antibody detecting CD35 in ELISA, IHC, WB. Suitable for Human.
Highlights
  • ●Recombinant — Superior batch-to-batch reproducibility with defined sequences.
  • ●Multi-Application — Validated across multiple applications.
Reactivité des espècesHuman
ApplicationsELISA, IHC, WB
Espèce hôteMouse
ClonalitéMonoclonal
IsotypeIgG
ID de clone1A629
Immunogène E. coli - derived recombinant human CD35/CR1 (Asp1740-Asp1971).
Cible Complement receptor type 1, C3b/C4b receptor, CD35, CR1
Niveau d'endotoxines Please contact with the lab for this information.
Pureté >95% as determined by SDS-PAGE.
Purification Protein A/G purified from cell culture supernatant.
Numéro d'accès P17927
Forme Liquid
Tampon de stockage 0.01M PBS pH 7.4.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Stabilité et stockage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Contexte

Complement receptor type 1 (CD35/CR1) is a ~223 kDa protein. Membrane immune adherence receptor that plays a critical role in the capture and clearance of complement-opsonized pathogens by erythrocytes and monocytes/macrophages. Mediates the binding by these cells of particles and immune complexes that have activated complement to eliminate them from the circulation. Also acts in the inhibition of spontaneous complement activation by impairing the formation and function of the alternative and classical pathway C3/C5 convertases, and by serving as a cofactor for the cleavage by factor I of C3b to iC3b, C3c and C3d,g, and of C4b to C4c and C4d. Also plays a role in immune regulation by contributing, upon ligand binding, to the generation of regulatory T cells from activated helper T cells.

1. Schifferli, JA. et al. (1988) Journal of immunology (Baltimore, Md. : 1950) 140, 899-904. PMID: 2963069
2. Klickstein, LB. et al. (1988) The Journal of experimental medicine 168, 1699-717. PMID: 2972794
3. Krych, M. et al. (1994) The Journal of biological chemistry 269, 13273-8. PMID: 8175757
4. Török, K. et al. (2015) Immunology letters 164, 117-24. PMID: 25742728
Note For research use only.
Images
  • Anti-Human CD35 Monoclonal Antibody (1A629)

    SDS-PAGE

    SDS-PAGE for Anti-Human CD35/CR1 Monoclonal Antibody (1A629)

Reférences
Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
×
Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
Recommandation

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