

| Каталожный номер | HV029237 |
|---|---|
| Реактивность видов | Human |
| Применения | FCM |
| Хозяинский вид | Human |
| Клоональность | Monoclonal |
| Изотип | IgG4, kappa |
| ID клона | SAA0101 |
| Конъюгация | APC |
| Цель | CD366, HAVCR2, HAVcr-2, Hepatitis A virus cellular receptor 2, T-cell immunoglobulin and mucin domain-containing protein 3, T-cell immunoglobulin mucin receptor 3, T-cell membrane protein 3, TIM-3, TIM3, TIMD-3, TIMD3 |
| Уровень эндотоксинов | Please contact with the lab for this information. |
| Чистота | >90% as determined by SDS-PAGE. |
| Связанные продукты | Human IgG4 (S228P) Recombinant Isotype Control Antibody (13R4), APC |
| Номер доступа | Q8TDQ0 |
| Форма | Liquid |
| Буфер хранения | 0.01M PBS, pH 7.4, 50% glycerol, 0.05% Proclin 300. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии. |
| Устойчивость и хранение | Store at 4°C for 12 months. Protect from light. Do not freeze. |
| Фон | Hepatitis A virus cellular receptor 2 (CD366/TIM-3) is a ~33 kDa protein. Cell surface receptor implicated in modulating innate and adaptive immune responses. Generally accepted to have an inhibiting function. Reports on stimulating functions suggest that the activity may be influenced by the cellular context and/or the respective ligand. Regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. 1. Gorman, JV. et al. (2014) Immunologic research 59, 56-65. PMID: 24825777 2. Monney, L. et al. (2002) Nature 415, 536-41. PMID: 11823861 3. Sánchez-Fueyo, A. et al. (2003) Nature immunology 4, 1093-101. PMID: 14556005 4. Clayton, KL. et al. (2014) Journal of immunology (Baltimore, Md. : 1950) 192, 782-91. PMID: 24337741 5. Tomkowicz, B. et al. (2015) PloS one 10, e0140694. PMID: 26492563 6. Gautron, AS. et al. (2014) European journal of immunology 44, 2703-2711. PMID: 24838857 7. Zhu, C. et al. (2005) Nature immunology 6, 1245-52. PMID: 16286920 8. Leitner, J. et al. (2013) PLoS pathogens 9, e1003253. PMID: 23555261 9. Gleason, MK. et al. (2012) Blood 119, 3064-72. PMID: 22323453 |
| Примечание | For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only. |




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