Anti-Human TIM-3 Recombinant Antibody (TSR-022), PE (HV029127)

Name: Anti-Human TIM-3 Recombinant Antibody (TSR-022), PE
Brand: abinScience
SKU: HV029127
Price: 290 USD
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Número de catálogo	HV029127
Reactividad de especies	Human
Aplicaciones	FCM
Especie huésped	Human
Clonalidad	Monoclonal
Isotipo	IgG4, kappa
ID de clon	TSR-022
Conjugación	PE
Objetivo	CD366, HAVCR2, HAVcr-2, Hepatitis A virus cellular receptor 2, T-cell immunoglobulin and mucin domain-containing protein 3, T-cell immunoglobulin mucin receptor 3, T-cell membrane protein 3, TIM-3, TIM3, TIMD-3, TIMD3
Nivel de endotoxinas	Please contact with the lab for this information.
Pureza	>90% as determined by SDS-PAGE.
Productos asociados	Human IgG4 (S228P) Recombinant Isotype Control Antibody (13R4), PE
Número de acceso	Q8TDQ0
Forma	Liquid
Buffer de almacenamiento	0.01M PBS, pH 7.4, 50% glycerol, 0.05% Proclin 300. Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Estabilidad y almacenamiento	Store at 4°C for 12 months. Protect from light. Do not freeze.
Fondo	Hepatitis A virus cellular receptor 2 (CD366/TIM-3) is a ~33 kDa protein. Cell surface receptor implicated in modulating innate and adaptive immune responses. Generally accepted to have an inhibiting function. Reports on stimulating functions suggest that the activity may be influenced by the cellular context and/or the respective ligand. Regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. _x005F_x000D_ _x005F_x000D_ 1. Gorman, JV. et al. (2014) Immunologic research 59, 56-65. PMID: 24825777 _x005F_x000D_ _x005F_x000D_ 2. Monney, L. et al. (2002) Nature 415, 536-41. PMID: 11823861 _x005F_x000D_ _x005F_x000D_ 3. Sánchez-Fueyo, A. et al. (2003) Nature immunology 4, 1093-101. PMID: 14556005 _x005F_x000D_ _x005F_x000D_ 4. Clayton, KL. et al. (2014) Journal of immunology (Baltimore, Md. : 1950) 192, 782-91. PMID: 24337741 _x005F_x000D_ _x005F_x000D_ 5. Tomkowicz, B. et al. (2015) PloS one 10, e0140694. PMID: 26492563 _x005F_x000D_ _x005F_x000D_ 6. Gautron, AS. et al. (2014) European journal of immunology 44, 2703-2711. PMID: 24838857 _x005F_x000D_ _x005F_x000D_ 7. Zhu, C. et al. (2005) Nature immunology 6, 1245-52. PMID: 16286920 _x005F_x000D_ _x005F_x000D_ 8. Leitner, J. et al. (2013) PLoS pathogens 9, e1003253. PMID: 23555261 _x005F_x000D_ _x005F_x000D_ 9. Gleason, MK. et al. (2012) Blood 119, 3064-72. PMID: 22323453
Nota	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.