Anti-Human TIM-3 Recombinant Antibody (TSR-022), PE (HV029127)

Name: Anti-Human TIM-3 Recombinant Antibody (TSR-022), PE
Brand: abinScience
SKU: HV029127
Price: 290 USD
Availability: InStock

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Numéro de catalogue	HV029127
Reactivité des espèces	Human
Applications	FCM
Espèce hôte	Human
Clonalité	Monoclonal
Isotype	IgG4, kappa
ID de clone	TSR-022
Conjugaison	PE
Cible	CD366, HAVCR2, HAVcr-2, Hepatitis A virus cellular receptor 2, T-cell immunoglobulin and mucin domain-containing protein 3, T-cell immunoglobulin mucin receptor 3, T-cell membrane protein 3, TIM-3, TIM3, TIMD-3, TIMD3
Niveau d'endotoxines	Please contact with the lab for this information.
Pureté	>90% as determined by SDS-PAGE.
Produits associés	Human IgG4 (S228P) Recombinant Isotype Control Antibody (13R4), PE
Numéro d'accès	Q8TDQ0
Forme	Liquid
Tampon de stockage	0.01M PBS, pH 7.4, 50% glycerol, 0.05% Proclin 300. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Stabilité et stockage	Store at 4°C for 12 months. Protect from light. Do not freeze.
Contexte	Hepatitis A virus cellular receptor 2 (CD366/TIM-3) is a ~33 kDa protein. Cell surface receptor implicated in modulating innate and adaptive immune responses. Generally accepted to have an inhibiting function. Reports on stimulating functions suggest that the activity may be influenced by the cellular context and/or the respective ligand. Regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. _x005F_x000D_ _x005F_x000D_ 1. Gorman, JV. et al. (2014) Immunologic research 59, 56-65. PMID: 24825777 _x005F_x000D_ _x005F_x000D_ 2. Monney, L. et al. (2002) Nature 415, 536-41. PMID: 11823861 _x005F_x000D_ _x005F_x000D_ 3. Sánchez-Fueyo, A. et al. (2003) Nature immunology 4, 1093-101. PMID: 14556005 _x005F_x000D_ _x005F_x000D_ 4. Clayton, KL. et al. (2014) Journal of immunology (Baltimore, Md. : 1950) 192, 782-91. PMID: 24337741 _x005F_x000D_ _x005F_x000D_ 5. Tomkowicz, B. et al. (2015) PloS one 10, e0140694. PMID: 26492563 _x005F_x000D_ _x005F_x000D_ 6. Gautron, AS. et al. (2014) European journal of immunology 44, 2703-2711. PMID: 24838857 _x005F_x000D_ _x005F_x000D_ 7. Zhu, C. et al. (2005) Nature immunology 6, 1245-52. PMID: 16286920 _x005F_x000D_ _x005F_x000D_ 8. Leitner, J. et al. (2013) PLoS pathogens 9, e1003253. PMID: 23555261 _x005F_x000D_ _x005F_x000D_ 9. Gleason, MK. et al. (2012) Blood 119, 3064-72. PMID: 22323453
Note	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.