Anti-Human TIM-3 Recombinant Nanobody (R53) (HV029023)

Name: Anti-Human TIM-3 Recombinant Nanobody (R53)
Brand: abinScience
SKU: HV029023
Price: 126 USD
Availability: InStock

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Especificación:

20ug
50ug
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1mg

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Contáctenos

Vista general
Imágenes
Referencias
Datasheet
SDS

Vista general

Número de catálogo

HV029023

Descripción

Anti-Human CD366/HAVCR2/TIM-3 Nanobody (R53) [R53] (HV029023) is a alpaca monoclonal antibody detecting HAVCR2 in ELISA, FCM. Suitable for Human.

Highlights

●Flow Cytometry — Validated for flow cytometry applications.

Reactividad de especies

Human

Aplicaciones

ELISA, FCM

Especie huésped

Alpaca

Clonalidad

Monoclonal

Isotipo

VHH-8His-Cys-tag

ID de clon

R53

Objetivo

CD366, HAVCR2, HAVcr-2, Hepatitis A virus cellular receptor 2, T-cell immunoglobulin and mucin domain-containing protein 3, T-cell immunoglobulin mucin receptor 3, T-cell membrane protein 3, TIM-3, TIM3, TIMD-3, TIMD3

Nivel de endotoxinas

< 10 EU/mg

Pureza

>95% as determined by SDS-PAGE.

Purificación

Purified by Nickel column

Número de acceso

Q8TDQ0

Forma

Liquid

Buffer de almacenamiento

0.01M PBS pH 7.4.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Información de uso del producto

Aplicación	Dilución
ELISA	1:2000-1:20000

Estabilidad y almacenamiento

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Fondo

Hepatitis A virus cellular receptor 2 (CD366/TIM-3) is a ~33 kDa protein. Cell surface receptor implicated in modulating innate and adaptive immune responses. Generally accepted to have an inhibiting function. Reports on stimulating functions suggest that the activity may be influenced by the cellular context and/or the respective ligand. Regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance.

1. Gorman, JV. et al. (2014) Immunologic research 59, 56-65. PMID: 24825777

2. Monney, L. et al. (2002) Nature 415, 536-41. PMID: 11823861

3. Sánchez-Fueyo, A. et al. (2003) Nature immunology 4, 1093-101. PMID: 14556005

4. Clayton, KL. et al. (2014) Journal of immunology (Baltimore, Md. : 1950) 192, 782-91. PMID: 24337741

5. Tomkowicz, B. et al. (2015) PloS one 10, e0140694. PMID: 26492563

6. Gautron, AS. et al. (2014) European journal of immunology 44, 2703-2711. PMID: 24838857

7. Zhu, C. et al. (2005) Nature immunology 6, 1245-52. PMID: 16286920

8. Leitner, J. et al. (2013) PLoS pathogens 9, e1003253. PMID: 23555261

9. Gleason, MK. et al. (2012) Blood 119, 3064-72. PMID: 22323453

Nota

For research use only.

Imágenes

SDS-PAGE

SDS-PAGE for Anti-Human CD366/HAVCR2/TIM-3 Nanobody (R53)

Referencias

Datasheet

Anti-Human TIM-3 Recombinant Nanobody (R53).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Proteínas Recombinantes

Anticuerpos

Kits de Ensayo