Anti-Human TIM-3 Recombinant Nanobody (R53) (HV029023)

Name: Anti-Human TIM-3 Recombinant Nanobody (R53)
Brand: abinScience
SKU: HV029023
Price: 126 USD
Availability: InStock

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Reférences
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SDS

Aperçu

Numéro de catalogue

HV029023

Description

Anti-Human CD366/HAVCR2/TIM-3 Nanobody (R53) [R53] (HV029023) is a alpaca monoclonal antibody detecting HAVCR2 in ELISA, FCM. Suitable for Human.

Highlights

●Flow Cytometry — Validated for flow cytometry applications.

Reactivité des espèces

Human

Applications

ELISA, FCM

Espèce hôte

Alpaca

Clonalité

Monoclonal

Isotype

VHH-8His-Cys-tag

ID de clone

R53

Cible

CD366, HAVCR2, HAVcr-2, Hepatitis A virus cellular receptor 2, T-cell immunoglobulin and mucin domain-containing protein 3, T-cell immunoglobulin mucin receptor 3, T-cell membrane protein 3, TIM-3, TIM3, TIMD-3, TIMD3

Niveau d'endotoxines

< 10 EU/mg

Pureté

>95% as determined by SDS-PAGE.

Purification

Purified by Nickel column

Numéro d'accès

Q8TDQ0

Forme

Liquid

Tampon de stockage

0.01M PBS pH 7.4.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:2000-1:20000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Contexte

Hepatitis A virus cellular receptor 2 (CD366/TIM-3) is a ~33 kDa protein. Cell surface receptor implicated in modulating innate and adaptive immune responses. Generally accepted to have an inhibiting function. Reports on stimulating functions suggest that the activity may be influenced by the cellular context and/or the respective ligand. Regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance.

1. Gorman, JV. et al. (2014) Immunologic research 59, 56-65. PMID: 24825777

2. Monney, L. et al. (2002) Nature 415, 536-41. PMID: 11823861

3. Sánchez-Fueyo, A. et al. (2003) Nature immunology 4, 1093-101. PMID: 14556005

4. Clayton, KL. et al. (2014) Journal of immunology (Baltimore, Md. : 1950) 192, 782-91. PMID: 24337741

5. Tomkowicz, B. et al. (2015) PloS one 10, e0140694. PMID: 26492563

6. Gautron, AS. et al. (2014) European journal of immunology 44, 2703-2711. PMID: 24838857

7. Zhu, C. et al. (2005) Nature immunology 6, 1245-52. PMID: 16286920

8. Leitner, J. et al. (2013) PLoS pathogens 9, e1003253. PMID: 23555261

9. Gleason, MK. et al. (2012) Blood 119, 3064-72. PMID: 22323453

Note

For research use only.

Images

SDS-PAGE

SDS-PAGE for Anti-Human CD366/HAVCR2/TIM-3 Nanobody (R53)

Reférences

Fiche technique

Anti-Human TIM-3 Recombinant Nanobody (R53).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

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