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Anti-Human CD367/CLEC4A Recombinant Antibody (9E8#), PerCP (HV145147)

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  • 100T
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Обзор
Каталожный номерHV145147
Реактивность видовHuman
ПримененияFCM
Хозяинский видMouse
КлоональностьMonoclonal
ИзотипIgG1, kappa
ID клона9E8#
КонъюгацияPerCP
Цель C-type lectin DDB27, CLECSF6, CLEC4A, LLIR, CD367, Lectin-like immunoreceptor, DCIR, C-type lectin domain family 4 member A, Dendritic cell immunoreceptor, C-type lectin superfamily member 6
Уровень эндотоксинов Please contact with the lab for this information.
Связанные продукты Mouse IgG1, kappa Recombinant Isotype Control Antibody (MOPC-21), PerCP
Номер доступа Q9UMR7
Форма Liquid
Буфер хранения 0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300.

Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.

Устойчивость и хранение Store at 4°C for 12 months. Protect from light. Do not freeze.
Фон

C-type lectin domain family 4 member A (CD367/CLEC4A) is a ~27 kDa protein. C-type lectin receptor that binds carbohydrates mannose and fucose but also weakly interacts with N-acetylglucosamine (GlcNAc) in a Ca(2+)-dependent manner. Involved in regulating immune reactivity. Once triggered by antigen, it is internalized by clathrin-dependent endocytosis and delivers its antigenic cargo into the antigen presentation pathway resulting in cross-priming of CD8(+) T cells. This cross-presentation and cross-priming are enhanced by TLR7 and TLR8 agonists with increased expansion of the CD8(+) T cells, high production of IFNG and TNF with reduced levels of IL4, IL5 and IL13. In plasmacytoid dendritic cells, inhibits TLR9-mediated IFNA and TNF production.

1. Nagae, M. et al. (2016) FEBS letters 590, 1280-8. PMID: 27015765
2. Bates, EE. et al. (1999) Journal of immunology (Baltimore, Md. : 1950) 163, 1973-83. PMID: 10438934
3. Meyer-Wentrup, F. et al. (2008) Blood 111, 4245-53. PMID: 18258799
4. Klechevsky, E. et al. (2010) Blood 116, 1685-97. PMID: 20530286
Примечание For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.
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