Anti-Human CD369/CLEC7A Recombinant Antibody (15E2#), APC (HV829137)

Name: Anti-Human CD369/CLEC7A Recombinant Antibody (15E2#), APC
Brand: abinScience
SKU: HV829137
Price: 290 USD
Availability: InStock

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Numéro de catalogue	HV829137
Reactivité des espèces	Human
Applications	FCM
Espèce hôte	Mouse
Clonalité	Monoclonal
Isotype	IgG1, kappa
ID de clone	15E2#
Conjugaison	APC
Cible	Beta-glucan receptor, CD369, CLEC7A, DECTIN1, BGR, C-type lectin superfamily member 12, DC-associated C-type lectin 1, CLECSF12, Dectin-1, C-type lectin domain family 7 member A, Dendritic cell-associated C-type lectin 1
Niveau d'endotoxines	Please contact with the lab for this information.
Produits associés	Mouse IgG1, kappa Recombinant Isotype Control Antibody (MOPC-21), APC
Numéro d'accès	Q9BXN2
Forme	Liquid
Tampon de stockage	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Stabilité et stockage	Store at 4°C for 12 months. Protect from light. Do not freeze.
Contexte	C-type lectin domain family 7 member A (CD369/CLEC7A) is a ~27 kDa protein. Lectin that functions as a pattern recognizing receptor (PRR) specific for beta-1,3-linked and beta-1,6-linked glucans, which constitute cell wall constituents from pathogenic bacteria and fungi. Necessary for the TLR2-mediated inflammatory response and activation of NF-kappa-B: upon beta-glucan binding, recruits SYK via its ITAM motif and promotes a signaling cascade that activates some CARD domain-BCL10-MALT1 (CBM) signalosomes, leading to the activation of NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines. Enhances cytokine production in macrophages and dendritic cells. Mediates production of reactive oxygen species in the cell. Mediates phagocytosis of C.albicans conidia. 1. Willment, JA. et al. (2001) The Journal of biological chemistry 276, 43818-23. PMID: 11567029 2. Grünebach, F. et al. (2002) Experimental hematology 30, 1309-15. PMID: 12423684 3. Kennedy, AD. et al. (2007) European journal of immunology 37, 467-78. PMID: 17230442
Note	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.

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Anti-Human CD369/CLEC7A Recombinant Antibody (15E2#), APC.pdf

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