Anti-Human CD37 Recombinant Antibody (HH1) (HY564107)

Name: Anti-Human CD37 Recombinant Antibody (HH1)
Brand: abinScience
SKU: HY564107
Price: 196 USD
Availability: InStock

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Изображения
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Даташит
SDS

Обзор

Каталожный номер	HY564107
Реактивность видов	Human
Применения	ELISA, FCM, IF, WB
Хозяинский вид	Mouse
Клоональность	Monoclonal
Изотип	IgG1, kappa
ID клона	HH1
Проверенные приложения	WB, FCM
Цель	CD37, Tspan-26, TSPAN26, Leukocyte antigen CD37, Tetraspanin-26
Уровень эндотоксинов	Please contact with the lab for this information.
Чистота	>95% as determined by SDS-PAGE.
Очистка	Protein A/G purified from cell culture supernatant.
Номер доступа	P11049
Форма	Liquid
Буфер хранения	0.01M PBS pH 7.4 Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.
Устойчивость и хранение	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Фон	Leukocyte antigen CD37 (TSPAN26) is a ~31 kDa protein. Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Participates thereby in diverse biological functions such as cell signal transduction, adhesion, migration and protein trafficking. Upon ligand binding, two signaling pathways are activated, one acting through phosphorylation by LYN leading to cell death or a survival pathway with activation of GSK3B. Plays an essential role essential for clustering of integrin ITGA4/ITGB1 and promotes its mobility in the plasma membrane of B-cells. In turn, participates in ITGA4/ITGB1 integrin-mediated antiapoptotic signaling through AKT. 1. Lapalombella, R. et al. (2012) Cancer cell 21, 694-708. PMID: 22624718 2. de Winde, CM. et al. (2016) The Journal of clinical investigation 126, 653-66. PMID: 26784544 3. Meyer-Wentrup, F. et al. (2007) Journal of immunology (Baltimore, Md. : 1950) 178, 154-62. PMID: 17182550
Примечание	For research use only.

Изображения

Bioactivity

SEC-HPLC detection for Anti-Human CD37/TSPAN26 Antibody (HH1).
Flow Cytometry

Flow-cytometry using anti-human CD37 antibody. U937 cells were stained with an irrelevant antibody (Blue Histogram) or an anti-human CD37 monoclonal antibody (Catalog HY564107, Yellow Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, bound antibody was detected using a a Goat Anti-Mouse IgG H&L Polyclonal Antibody, FITC (abinScience: MF690414) and cells analysed on a NovoCyte Flow Cytometer.
Western blot

Western blot analysis was performed using anti-CD37/TSPAN26 monoclonal antibody at 1μg/ml on various samples.
Lane 1: recombinant human CD37/TSPAN26 (Catalog No: HY564011), 50ng
Lane 2: recombinant human CD37/TSPAN26 (Catalog No: HY564011), 30ng
Lane 3: recombinant human CD37/TSPAN26 (Catalog No: HY564011), 20ng