Anti-Human MICL/CLEC12A Polyclonal Antibody (HV493014)

Name: Anti-Human MICL/CLEC12A Polyclonal Antibody
Brand: abinScience
SKU: HV493014
Price: 168 USD
Availability: InStock

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Spécification :

50ug
100ug

Nombre :

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Fiche technique
SDS

Aperçu

Numéro de catalogue

HV493014

Description

Anti-Human CD371/CLEC12A Polyclonal Antibody (HV493014) is a rabbit polyclonal antibody detecting CLEC12A in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Reactivité des espèces

Human

Applications

ELISA, IHC, WB

Espèce hôte

Rabbit

Clonalité

Polyclonal

Isotype

IgG

Immunogène

E. coli - derived recombinant Human CD371/CLEC12A (Arg136-Ala265).

Cible

C-type lectin domain family 12 member A, C-type lectin-like molecule 1, CLL-1, Dendritic cell-associated lectin 2, DCAL-2, Killer cell C-type lectin-like receptor L1, hKLRL1, Myeloid inhibitory C-type lectin-like receptor, MICL, CD371, CLEC12A, CLL1, DCAL2, KLRL1, MICL

Niveau d'endotoxines

Please contact with the lab for this information.

Pureté

>95% as determined by SDS-PAGE.

Purification

Purified by antigen affinity column.

Numéro d'accès

Q5QGZ9

Forme

Liquid

Tampon de stockage

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Contexte

C-type lectin domain family 12 member A (CD371/CLEC12A) is a ~30 kDa protein. Myeloid inhibitory C-type lectin receptor that acts as a negative regulator of myeloid cell activation. Myeloid cell inhibition is required to limit proinflammatory pathways and protect against excessive inflammation. Specifically recognizes and binds various structures, such as neutrophil extracellular traps (NETs) or monosodium urate crystals. Also acts as a pattern-recognition receptor for pathogen-associated molecules, such as plasmodium hemozoin or mycobacterial micolic acid. Ligand-binding induces phosphorylation of its ITIM motif, followed by recruitment of tyrosine-protein phosphatases PTPN6 and PTPN11, which counteract tyrosine-protein kinase SYK, thereby preventing myeloid cell activation.

1. Marshall, AS. et al. (2004) The Journal of biological chemistry 279, 14792-802. PMID: 14739280

2. Han, Y. et al. (2004) Blood 104, 2858-66. PMID: 15238421

3. Chen, CH. et al. (2006) Blood 107, 1459-67. PMID: 16239426

4. Paré, G. et al. (2021) Frontiers in immunology 12, 650808. PMID: 34234773

5. Tang, H. et al. (2024) The Journal of biological chemistry 300, 105765. PMID: 38367667

6. Mori, S. et al. (2024) International immunology 36, 279-290. PMID: 38386511

7. Malamud, M. et al. (2024) Nature 633, 442-450. PMID: 39143217

Note

For research use only

Images

Reférences

Fiche technique

Anti-Human MICL/CLEC12A Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Protéines Recombinantes

Anticorps

Kits d'Essai

Anti-Human MICL/CLEC12A Polyclonal Antibody (HV493014)

Aperçu

Images

Reférences

Fiche technique

SDS