Anti-Human MICL/CLEC12A Polyclonal Antibody (HV493014)

Name: Anti-Human MICL/CLEC12A Polyclonal Antibody
Brand: abinScience
SKU: HV493014
Price: 168 USD
Availability: InStock

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Каталожный номер

HV493014

Описание

Anti-Human CD371/CLEC12A Polyclonal Antibody (HV493014) is a rabbit polyclonal antibody detecting CLEC12A in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Реактивность видов

Human

Применения

ELISA, IHC, WB

Хозяинский вид

Rabbit

Клоональность

Polyclonal

Изотип

IgG

Иммуноген

E. coli - derived recombinant Human CD371/CLEC12A (Arg136-Ala265).

Цель

C-type lectin domain family 12 member A, C-type lectin-like molecule 1, CLL-1, Dendritic cell-associated lectin 2, DCAL-2, Killer cell C-type lectin-like receptor L1, hKLRL1, Myeloid inhibitory C-type lectin-like receptor, MICL, CD371, CLEC12A, CLL1, DCAL2, KLRL1, MICL

Уровень эндотоксинов

Please contact with the lab for this information.

Чистота

>95% as determined by SDS-PAGE.

Очистка

Purified by antigen affinity column.

Номер доступа

Q5QGZ9

Форма

Liquid

Буфер хранения

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.

Информация об использовании продукта

Применение	Разбавление
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Устойчивость и хранение

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Фон

C-type lectin domain family 12 member A (CD371/CLEC12A) is a ~30 kDa protein. Myeloid inhibitory C-type lectin receptor that acts as a negative regulator of myeloid cell activation. Myeloid cell inhibition is required to limit proinflammatory pathways and protect against excessive inflammation. Specifically recognizes and binds various structures, such as neutrophil extracellular traps (NETs) or monosodium urate crystals. Also acts as a pattern-recognition receptor for pathogen-associated molecules, such as plasmodium hemozoin or mycobacterial micolic acid. Ligand-binding induces phosphorylation of its ITIM motif, followed by recruitment of tyrosine-protein phosphatases PTPN6 and PTPN11, which counteract tyrosine-protein kinase SYK, thereby preventing myeloid cell activation.

1. Marshall, AS. et al. (2004) The Journal of biological chemistry 279, 14792-802. PMID: 14739280

2. Han, Y. et al. (2004) Blood 104, 2858-66. PMID: 15238421

3. Chen, CH. et al. (2006) Blood 107, 1459-67. PMID: 16239426

4. Paré, G. et al. (2021) Frontiers in immunology 12, 650808. PMID: 34234773

5. Tang, H. et al. (2024) The Journal of biological chemistry 300, 105765. PMID: 38367667

6. Mori, S. et al. (2024) International immunology 36, 279-290. PMID: 38386511

7. Malamud, M. et al. (2024) Nature 633, 442-450. PMID: 39143217

Примечание

For research use only

Изображения

Ссылки

Даташит

Anti-Human MICL/CLEC12A Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Рекомбинантные Белки

Антитела

Наборы для анализа

Anti-Human MICL/CLEC12A Polyclonal Antibody (HV493014)

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Изображения

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