Anti-Human CD3G Monoclonal Antibody (1A637) (HB395025)

Name: Anti-Human CD3G Monoclonal Antibody (1A637)
Brand: abinScience
SKU: HB395025
Price: 106 USD
Availability: InStock

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Numéro de catalogue	HB395025
Description	Anti-Human CD3G Monoclonal Antibody (1A637) [1A637] (HB395025) is a mouse monoclonal antibody detecting CD3g in ELISA, IHC, WB. Suitable for Human. Highlights ●Recombinant — Superior batch-to-batch reproducibility with defined sequences. ●Multi-Application — Validated across multiple applications.
Reactivité des espèces	Human
Applications	ELISA, IHC, WB
Espèce hôte	Mouse
Clonalité	Monoclonal
Isotype	IgG
ID de clone	1A637
Immunogène	Mammalian cells - derived recombinant human CD3G (Met1-Ser116).
Cible	T-cell surface glycoprotein CD3 gamma chain, T-cell receptor T3 gamma chain, CD3g, CD3G
Purification	Protein A/G purified from cell culture supernatant.
Numéro d'accès	P09693
Forme	Liquid
Tampon de stockage	0.01M PBS pH 7.4 Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Stabilité et stockage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Contexte	T-cell surface glycoprotein CD3 gamma chain (CD3G) is a ~20 kDa protein. Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD247/CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. In addition to this role of signal transduction in T-cell activation, CD3G plays an essential role in the dynamic regulation of TCR expression at the cell surface. 1. Barber, EK. et al. (1989) Proceedings of the National Academy of Sciences of the United States of America 86, 3277-81. PMID: 2470098 2. Dietrich, J. et al. (1994) The EMBO journal 13, 2156-66. PMID: 8187769
Note	For research use only.