Anti-Human Integrin alpha 2b/CD41 Recombinant Antibody (PT25) (HY355607)

Name: Anti-Human Integrin alpha 2b/CD41 Recombinant Antibody (PT25)
Brand: abinScience
SKU: HY355607
Price: 191 USD
Availability: InStock

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概要

カタログ番号	HY355607
種反応性	Human
アプリケーション	FCM
宿主種	Mouse
クローン性	Monoclonal
アイソタイプ	IgG1, kappa
クローンID	PT25
テスト済みアプリケーション	FCM
ターゲット	CD41, ITGAB, GPIIb, ITGA2B, Platelet membrane glycoprotein IIb, GP2B, Integrin alpha-IIb, GPalpha IIb
エンドトキシンレベル	Please contact with the lab for this information.
純度	>95% as determined by SDS-PAGE.
精製	Protein A/G purified from cell culture supernatant.
アクセッション番号	P08514
形態	Liquid
保存バッファー	0.01M PBS, pH 7.4, 0.09% Sodium azide. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。
安定性と保存	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
背景	Integrin alpha-IIb (CD41/ITGA2B) is a ~113 kDa protein. Integrin alpha-IIb/beta-3 (ITGA2B:ITGB3) is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface. 1. Si-Tahar, M. et al. (1997) The Journal of biological chemistry 272, 11636-47. PMID: 9111081 2. Hermand, P. et al. (2003) The Journal of biological chemistry 278, 4892-8. PMID: 12477717
注意事項	For research use only.

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Flow Cytometry

Flow-cytometry using anti-human CD41 antibody.Human peripheral blood monocytes were stained with an irrelevant antibody (Blue Histogram) or an anti-human CD41 antibody monoclonal antibody (Catalog # HY355607 ,Green Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, bound antibody was detected using a FITC conjugated goat anti-mouse antibody (Catalog # MF690414) and cells analysed on a NovoCyte Flow Cytometer.

参考文献

データシート

Anti-Human Integrin alpha 2b/CD41 Recombinant Antibody (PT25).pdf

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Anti-Human Integrin alpha 2b/CD41 Recombinant Antibody (PT25) (HY355607)

概要

イメージ

参考文献

データシート

SDS

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