Anti-Human CD69 Recombinant Antibody (SAA0819) (HC273207)

Name: Anti-Human CD69 Recombinant Antibody (SAA0819)
Brand: abinScience
SKU: HC273207
Price: 191 USD
Availability: InStock

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Aperçu

Numéro de catalogue	HC273207
Reactivité des espèces	Human
Applications	FCM
Espèce hôte	Rabbit
Clonalité	Monoclonal
Isotype	IgG
ID de clone	SAA0819
Cible	AIM, CD69, C-type lectin domain family 2 member C, Early T-cell activation antigen p60, BL-AC/P26, GP32/28, MLR-3, Early activation antigen CD69, Leukocyte surface antigen Leu-23, CLEC2C, EA1, Activation inducer molecule
Niveau d'endotoxines	Please contact with the lab for this information.
Pureté	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Numéro d'accès	Q07108
Forme	Liquid
Tampon de stockage	0.01M PBS, pH 7.4, 0.09% Sodium azide. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Stabilité et stockage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Contexte	Early activation antigen CD69 is a ~22 kDa protein. Transmembrane protein expressed mainly on T-cells resident in mucosa that plays an essential role in immune cell homeostasis. Rapidly expressed on the surface of platelets, T-lymphocytes and NK cells upon activation by various stimuli, such as antigen recognition or cytokine signaling, stimulates different signaling pathways in different cell types. Negatively regulates Th17 cell differentiation through its carbohydrate dependent interaction with galectin-1/LGALS1 present on immature dendritic cells. Association of CD69 cytoplasmic tail with the JAK3/STAT5 signaling pathway regulates the transcription of RORgamma/RORC and, consequently, differentiation toward the Th17 lineage. Also acts via the S100A8/S100A9 complex present on peripheral blood mononuclear cells to promote the conversion of naive CD4 T-cells into regulatory T-cells. 1. de la Fuente, H. et al. (2014) Molecular and cellular biology 34, 2479-87. PMID: 24752896 2. Lin, CR. et al. (2015) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 29, 5006-17. PMID: 26296369 3. Jiménez-Fernández, M. et al. (2022) Cellular and molecular life sciences : CMLS 79, 468. PMID: 35930205 4. Jiang, Y. et al. (2021) Clinical and translational medicine 11, e563. PMID: 34841721 5. Chen, H. et al. (2023) eLife 12. PMID: 37039481
Note	For research use only.

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SDS-PAGE for Anti-Human CD69 Antibody (SAA0819)

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Anti-Human CD69 Recombinant Antibody (SAA0819).pdf

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