Anti-Human CD81 Recombinant Antibody (5A6), APC (HX855137)

Name: Anti-Human CD81 Recombinant Antibody (5A6), APC
Brand: abinScience
SKU: HX855137
Price: 214 USD
Availability: InStock

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Número de catálogo	HX855137
Reactividad de especies	Human
Aplicaciones	FCM, WB
Especie huésped	Mouse
Clonalidad	Monoclonal
Isotipo	IgG1, kappa
ID de clon	5A6
Conjugación	APC
Objetivo	CD81 antigen, TSPAN28, Target of the antiproliferative antibody 1, Tspan-28, Tetraspanin-28, CD81, TAPA1, 26 kDa cell surface protein TAPA-1
Nivel de endotoxinas	Please contact with the lab for this information.
Productos asociados	Mouse IgG1, kappa Recombinant Isotype Control Antibody (MOPC-21), APC
Número de acceso	P60033
Forma	Liquid
Buffer de almacenamiento	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Estabilidad y almacenamiento	Store at 4°C for 12 months. Protect from light. Do not freeze.
Fondo	CD81 antigen is a ~25 kDa protein. Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Essential for trafficking and compartmentalization of CD19 receptor on the surface of activated B cells. Upon initial encounter with microbial pathogens, enables the assembly of CD19-CR2/CD21 and B cell receptor (BCR) complexes at signaling TERMs, lowering the threshold dose of antigen required to trigger B cell clonal expansion and antibody production. In T cells, facilitates the localization of CD247/CD3 zeta at antigen-induced synapses with B cells, providing for costimulation and polarization toward T helper type 2 phenotype. Present in MHC class II compartments, may also play a role in antigen presentation. 1. Shoham, T. et al. (2006) Molecular and cellular biology 26, 1373-85. PMID: 16449649 2. van Zelm, MC. et al. (2010) The Journal of clinical investigation 120, 1265-74. PMID: 20237408 3. Zimmerman, B. et al. (2016) Cell 167, 1041-1051.e11. PMID: 27881302 4. Cherukuri, A. et al. (2004) The Journal of biological chemistry 279, 31973-82. PMID: 15161911 5. Sagi, Y. et al. (2012) Proceedings of the National Academy of Sciences of the United States of America 109, 1613-8. PMID: 22307619 6. Rocha-Perugini, V. et al. (2013) Molecular and cellular biology 33, 3644-58. PMID: 23858057 7. Secrist, H. et al. (1996) European journal of immunology 26, 1435-42. PMID: 8766544 8. Schick, MR. et al. (1993) Journal of immunology (Baltimore, Md. : 1950) 151, 4090-7. PMID: 8409388 9. Takeda, Y. et al. (2003) The Journal of cell biology 161, 945-56. PMID: 12796480
Nota	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.

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Anti-Human CD81 Recombinant Antibody (5A6), APC.pdf

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