Anti-Human LILRB2/CD85d/ILT4 Recombinant Antibody (J19.H1), APC (HV255137)

Name: Anti-Human LILRB2/CD85d/ILT4 Recombinant Antibody (J19.H1), APC
Brand: abinScience
SKU: HV255137
Price: 290 USD
Availability: InStock

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概要
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参考文献
データシート
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概要

カタログ番号	HV255137
種反応性	Human
アプリケーション	FCM
宿主種	Mouse
クローン性	Monoclonal
アイソタイプ	IgG1, kappa
クローンID	J19.H1
抱合	APC
ターゲット	CD85 antigen-like family member D, Monocyte/macrophage immunoglobulin-like receptor 10, MIR-10, ILT4, LIR-2, ILT-4, Immunoglobulin-like transcript 4, MIR10, CD85d, Leukocyte immunoglobulin-like receptor subfamily B member 2, Leukocyte immunoglobulin-like receptor 2, LIR2, LILRB2
エンドトキシンレベル	Please contact with the lab for this information.
関連製品	Mouse IgG1, kappa Recombinant Isotype Control Antibody (MOPC-21), APC
アクセッション番号	Q8N423
形態	Liquid
保存バッファー	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。
安定性と保存	Store at 4°C for 12 months. Protect from light. Do not freeze.
背景	Leukocyte immunoglobulin-like receptor subfamily B member 2 (CD85d/LILRB2) is a ~65 kDa protein. Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C, HLA-G and HLA-F alleles. Involved in the down-regulation of the immune response and the development of tolerance. Recognizes HLA-G in complex with B2M/beta-2 microglobulin and a nonamer self-peptide (peptide-bound HLA-G-B2M) triggering differentiation of type 1 regulatory T cells and myeloid-derived suppressor cells, both of which actively maintain maternal-fetal tolerance. Competes with CD8A for binding to class I MHC antigens. 1. Lepin, EJ. et al. (2000) European journal of immunology 30, 3552-61. PMID: 11169396 2. Shiroishi, M. et al. (2003) Proceedings of the National Academy of Sciences of the United States of America 100, 8856-61. PMID: 12853576 3. Shiroishi, M. et al. (2006) The Journal of biological chemistry 281, 10439-47. PMID: 16455647 4. Gregori, S. et al. (2010) Blood 116, 935-44. PMID: 20448110 5. Köstlin, N. et al. (2017) European journal of immunology 47, 374-384. PMID: 27859042 6. Chang, CC. et al. (2002) Nature immunology 3, 237-43. PMID: 11875462 8. Fanger, NA. et al. (1998) European journal of immunology 28, 3423-34. PMID: 9842885
注意事項	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.