Anti-Human Complement Component C5aR1 Recombinant Antibody (SAA0039), PE (HB064127)

Name: Anti-Human Complement Component C5aR1 Recombinant Antibody (SAA0039), PE
Brand: abinScience
SKU: HB064127
Price: 290 USD
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Número de catálogo	HB064127
Reactividad de especies	Human
Aplicaciones	FCM
Especie huésped	Human
Clonalidad	Monoclonal
Isotipo	IgG1, kappa
ID de clon	SAA0039
Conjugación	PE
Objetivo	CD88, C5AR1, C5R1, C5AR, C5a-R, C5aR, C5a anaphylatoxin chemotactic receptor 1, C5a anaphylatoxin chemotactic receptor
Nivel de endotoxinas	Please contact with the lab for this information.
Productos asociados	Human IgG1 Recombinant Isotype Control Antibody (HyHEL-10), PE
Número de acceso	P21730
Forma	Liquid
Buffer de almacenamiento	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Estabilidad y almacenamiento	Store at 4°C for 12 months. Protect from light. Do not freeze.
Fondo	C5a anaphylatoxin chemotactic receptor 1 (CD88/C5AR1) is a ~39 kDa protein. Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a, stimulating chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. C5AR1 is coupled to G(i)/G(o) (GNAI1 or GNAO1) G alpha proteins and mediates inhibition of adenylate cyclase. The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events. 1. Christophe, T. et al. (2000) The Journal of biological chemistry 275, 1656-64. PMID: 10636859 2. Postma, B. et al. (2004) Journal of immunology (Baltimore, Md. : 1950) 172, 6994-7001. PMID: 15153520 3. Gerard, NP. et al. (1991) Nature 349, 614-7. PMID: 1847994 4. Robertson, N. et al. (2018) Nature 553, 111-114. PMID: 29300009 5. Feng, Y. et al. (2023) Cell research 33, 312-324. PMID: 36806352 6. Monk, PN. et al. (1995) The Journal of biological chemistry 270, 16625-9. PMID: 7622471 7. DeMartino, JA. et al. (1994) The Journal of biological chemistry 269, 14446-50. PMID: 8182049 8. Chen, Z. et al. (1998) The Journal of biological chemistry 273, 10411-9. PMID: 9553099 9. Yadav, MK. et al. (2023) Cell 186, 4956-4973.e21. PMID: 37852260
Nota	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.