Anti-Human CD93/C1qR Recombinant Antibody (070-016), APC (HV345137)

Name: Anti-Human CD93/C1qR Recombinant Antibody (070-016), APC
Brand: abinScience
SKU: HV345137
Price: 290 USD
Availability: InStock

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Каталожный номер	HV345137
Реактивность видов	Human
Применения	FCM
Хозяинский вид	Mouse
Клоональность	Monoclonal
Изотип	IgG1, kappa
ID клона	070-016
Конъюгация	APC
Цель	Matrix-remodeling-associated protein 4, C1q/MBL/SPA receptor, C1qRp, C1QR1, C1qR, Complement component 1 q subcomponent receptor 1, CD93, Complement component C1q receptor, MXRA4, CDw93, C1qR(p)
Уровень эндотоксинов	Please contact with the lab for this information.
Связанные продукты	Mouse IgG1, kappa Recombinant Isotype Control Antibody (MOPC-21), APC
Номер доступа	Q9NPY3
Форма	Liquid
Буфер хранения	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.
Устойчивость и хранение	Store at 4°C for 12 months. Protect from light. Do not freeze.
Фон	Complement component C1q receptor (CD93/C1qR) is a ~68 kDa protein. Cell surface receptor that plays a role in various physiological processes including inflammation, phagocytosis, and cell adhesion. Plays a role in phagocytosis and enhances the uptake of apoptotic cells and immune complexes by acting as a receptor for defense collagens including surfactant protein A/SFTPA1, C1q, and mannose-binding lectin (MBL2). Plays a role in the regulation of endothelial cell function and adhesion by activating angiogenesis. Mechanistically, exerts its angiogenic function by associating with beta-dystroglycan, leading to SRC-dependent phosphorylation and subsequent recruitment of CBL. In turn, CBL provides a docking site for downstream signaling components, such as CRKL to enhance cell migration. 1. Geertsma, MF. et al. (1994) The American journal of physiology 267, L578-84. PMID: 7977768 2. Orlandini, M. et al. (2014) Oncotarget 5, 2750-60. PMID: 24809468 3. Galvagni, F. et al. (2016) Oncotarget 7, 10090-103. PMID: 26848865 4. Khan, KA. et al. (2017) Oncogene 36, 6097-6108. PMID: 28671670 5. Barbera, S. et al. (2023) International journal of biological macromolecules 224, 453-464. PMID: 36265539 6. Xu, Y. et al. (2024) Structure (London, England : 1993) 32, 282-291.e4. PMID: 38218180
Примечание	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.

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Flow CytoMetry

Flow-cytometry using APC anti-human CD93 antibody. U937 cells were stained with an irrelevant antibody (Blue Histogram) or an APC anti-human CD93 monoclonal antibody (Catalog: HV345137, Yellow Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, cells analysed on a NovoCyte Flow Cytometer.

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