Anti-Human CD98/SLC3A2 Recombinant Antibody (Ab110), APC (HY415137)

Name: Anti-Human CD98/SLC3A2 Recombinant Antibody (Ab110), APC
Brand: abinScience
SKU: HY415137
Price: 290 USD
Availability: InStock

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Aperçu

Numéro de catalogue	HY415137
Reactivité des espèces	Human
Applications	FCM
Espèce hôte	Mouse
Clonalité	Monoclonal
Isotype	IgG1, kappa
ID de clone	Ab110
Conjugaison	APC
Cible	SLC3A2, 4F2hc, Lymphocyte activation antigen 4F2 large subunit, CD98, 4F2 cell-surface antigen heavy chain, Solute carrier family 3 member 2, MDU1, 4F2 heavy chain antigen
Niveau d'endotoxines	Please contact with the lab for this information.
Produits associés	Mouse IgG1, kappa Recombinant Isotype Control Antibody (MOPC-21), APC
Numéro d'accès	P08195
Forme	Liquid
Tampon de stockage	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Stabilité et stockage	Store at 4°C for 12 months. Protect from light. Do not freeze.
Contexte	Amino acid transporter heavy chain SLC3A2 (CD98) is a ~57 kDa protein. Acts as a chaperone that facilitates biogenesis and trafficking of functional transporters heterodimers to the plasma membrane. Forms heterodimer with SLC7 family transporters (SLC7A5, SLC7A6, SLC7A7, SLC7A8, SLC7A10 and SLC7A11), a group of amino-acid antiporters. Heterodimers function as amino acids exchangers, the specificity of the substrate depending on the SLC7A subunit. Heterodimers SLC3A2/SLC7A6 or SLC3A2/SLC7A7 mediate the uptake of dibasic amino acids. Heterodimer SLC3A2/SLC7A11 functions as an antiporter by mediating the exchange of extracellular anionic L-cystine and intracellular L-glutamate across the cellular plasma membrane. 1. Rossier, G. et al. (1999) The Journal of biological chemistry 274, 34948-54. PMID: 10574970 2. Bröer, A. et al. (2000) The Biochemical journal 349 Pt 3, 787-95. PMID: 10903140 3. Yanagida, O. et al. (2001) Biochimica et biophysica acta 1514, 291-302. PMID: 11557028 4. Yan, R. et al. (2019) Nature 568, 127-130. PMID: 30867591 5. Yan, R. et al. (2020) Cell discovery 6, 82. PMID: 33298890 6. Yan, R. et al. (2021) Cell discovery 7, 16. PMID: 33758168 7. Parker, JL. et al. (2021) Nature communications 12, 7147. PMID: 34880232 8. Mastroberardino, L. et al. (1998) Nature 395, 288-91. PMID: 9751058 9. Torrents, D. et al. (1998) The Journal of biological chemistry 273, 32437-45. PMID: 9829974 10. Pfeiffer, R. et al. (1999) The EMBO journal 18, 49-57. PMID: 9878049
Note	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.

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Flow CytoMetry

Flow-cytometry using APC anti-human CD98 antibody. Hela cells were stained with an irrelevant antibody (Blue Histogram) or an APC anti-human CD98 monoclonal antibody (Catalog: HY415137, Yellow Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, cells analysed on a NovoCyte Flow Cytometer.

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